Epstein-Barr Virus-Associated Primary Central Nervous System Lymphoma in the Japanese Population
Epstein-Barr Virus-Associated Primary Central Nervous System Lymphoma in the Japanese Population
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DOI：
10.2176/nmc.50.114
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发表时间：
2010-02-01
影响因子：
1.9
通讯作者：
Kubota, Toshihiko
中科院分区：
文献类型：
--
作者：
Kitai, Ryuhei;Matsuda, Ken;Kubota, Toshihiko
使用 EBV 编码的小核糖核酸-1 (EBER-1) 原位杂交评估了日本 Epstein-Barr 病毒 (EBV) 相关的原发性中枢神经系统 (CNS) 淋巴瘤的发病率，以确定 22 例福尔马林固定和石蜡包埋的原发性 CNS 淋巴瘤中是否存在 EBV。所有病例均为B细胞淋巴瘤。 22例原发性中枢神经系统淋巴瘤病例中有3例（13.6%）的细胞核中观察到EBER-1表达。日本病例中 EBV 阳性淋巴瘤的发病率高于西方国家此前报道的病例。 EBV 阳性原发性中枢神经系统淋巴瘤患者的生存期比肿瘤阴性患者短（中位 4 个月 vs. 26 个月）。 EBER-1 原位杂交检测 EBV 感染快速可靠。不常见的关联表明这些肿瘤的进化存在不同的发病机制。 EBV 相关原发性中枢神经系统淋巴瘤发病率的地域差异可能反映了流行病学因素。
The incidence of Epstein-Barr virus (EBV)-associated primary central nervous system (CNS) lymphoma in Japan was assessed using in situ hybridization of EBV-encoded small ribonucleic acid-1 (EBER-1) to identify the presence of EBV in 22 cases of formalin-fixed and paraffin-embedded primary CNS lymphoma. All cases were B-cell lymphoma. EBER-1 expression was observed in the nuclei of 3 of 22 primary CNS lymphoma cases (13.6%). The incidence of EBV-positive lymphoma in Japanese cases is higher than previously reported from Western countries. Patients with EBV-positive primary CNS lymphoma showed shorter survival than those with negative tumors (median 4 months vs. 26 months). EBER-1 in situ hybridization for the detection of EBV infection is rapid and reliable. Infrequent association suggests a different pathogenetic mechanism in the evolution of these tumors. Geographical differences in the incidence of EBV-associated primary CNS lymphoma may reflect epidemiological factors.