Long-term consolidation and retention of learning-induced tuning plasticity in the auditory cortex of the guinea pig
Long-term consolidation and retention of learning-induced tuning plasticity in the auditory cortex of the guinea pig
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DOI：
10.1006/nlme.2001.4044
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发表时间：
2002-01-01
影响因子：
2.7
通讯作者：
Weinberger, NM
中科院分区：
文献类型：
--
作者：
Galván, VV;Weinberger, NM
本研究的主要目的是确定是否经典条件反射产生长期的神经巩固的频率调谐可塑性的听觉皮层。从长期植入的成年雄性Hartley豚鼠获得局部场电位（LFP），将其分为调节组（n = 4）和致敏对照组（n = 3）。在训练前即刻以及训练后1小时、1、3、7和10天，测定清醒受试者的平均LFP（类似于0.4至36.0 kHz，-20至80 dB）的调谐功能;致敏受试者没有进行10天的保持测试。条件反射包括30 - 45次6 s音调（CS，70 dB）的单次试验，该频率不是最佳频率（BF，调谐曲线的峰值），然后在CS偏移处进行短暂的莱亚电击（US）。致敏对照动物接受相同密度的CS和US呈现，未配对。心率记录显示，条件化组出现条件性心动过缓，而致敏对照组没有。局部场电位在空调组，但不是在敏化组，开发调谐可塑性。CS频率与BF的反应比在训练后1小时增加，并且这种增加在研究的10天期间被保留。调谐可塑性和保留观察跨刺激水平（10-80分贝）。最值得注意的是，调谐塑性表现出固结（即，在保留期内产生更大的CS特异性效应），在3天时达到渐近线。研究结果表明，听觉皮层的LFPs具有行为记忆的三个基本特征：联想调谐可塑性，长期保持和长期巩固。潜在的细胞和亚细胞机制LFP调谐可塑性和长期巩固进行了讨论。(C)2002年，Elsevier Science。
The major goal of this study was to determine whether classical conditioning produces long-term neural consolidation of frequency tuning plasticity in the auditory cortex. Local field potentials (LFPs) were obtained from chronically implanted adult male Hartley guinea pigs that were divided into conditioning (n = 4) and sensitization control (n = 3) groups. Tuning functions were determined in awake subjects for average LFPs (similar to0.4 to 36.0 kHz, -20 to 80 dB) immediately before training as well as I h and 1, 3, 7, and 10 days after training; sensitization subjects did not have a 10-day retention test. Conditioning consisted of a single session of 30 to 45 trials of a 6-s tone (CS, 70 dB) that was not the best frequency (BF, peak of a tuning curve), followed by a brief lea shock (US) at CS offset. Sensitization control animals received the same density of CS and US presentations unpaired. Heart rate recordings showed that the conditioning group developed conditioned bradycardia, whereas the sensitization control group did not. Local field potentials in the conditioning group, but not in the sensitization group, developed tuning plasticity. The ratio of responses to the CS frequency versus the BF were increased I h after training, and this increase was retained for the 10-day period of the study. Both tuning plasticity and retention were observed across stimulus levels (10-80 dB). Most noteworthy, tuning plasticity exhibited consolidation (i.e., developed greater CS-specific effects across retention periods), attaining asymptote at 3 days. The findings indicate that LFPs in the auditory cortex have three cardinal features of behavioral memory: associative tuning plasticity, long-term retention, and long-term consolidation. Potential cellular and subcellular mechanisms of LFP tuning plasticity and long-term consolidation are discussed. (C) 2002 Elsevier Science.