Myrica cerifera, a Medicinal Plant of the Lumbee Tribe, has Antibacterial and Nematicidal Properties.
Myrica cerifera, a Medicinal Plant of the Lumbee Tribe, has Antibacterial and Nematicidal Properties.
复制标题
DOI：
10.33697/ajur.2022.054
复制
发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
Alexander, Courtney Carroll
中科院分区：
文献类型：
--
作者：
Edwards, Ashley;Deberry, Kazhmiri;Mariani, Hannah;Taylor, Darian H;Cochran, Nicholas J;Barrios Sosa, Ana C;Scott, Andrea Regan;Williamson, R Thomas;Tirla, Cornelia;Sandefur, Conner;Alexander, Courtney Carroll
目前威胁医学界的是越来越多的耐抗生素疾病。更具体地说，细菌和线虫分别对世界上许多主要的抗生素和杀线虫剂产生了耐药性，这使得感染更难以治疗。随后，这些寄生生物能够在没有强烈干扰的情况下继续破坏农作物和其他生物，如人类。为了帮助人类和环境，开发新型抗生素至关重要。先前的研究表明，植物化学物质是一种潜在的解决方案，不仅有助于抑制细菌生长，而且还能降低线虫的存活率。我们假设杨梅，一种经常被蓝蜂部落用来治疗疾病的植物，具有抗菌和杀线虫的特性。为了回答我们的假设，我们开始收集植物标本，提取用于生物分析的材料，随后分离和阐明活性成分的结构。用琼脂扩散法测定提取物的抗菌性能，然后用秀丽隐杆线虫测定提取物的杀线虫性能。在琼脂草坪上添加不同剂量的鸢尾提取物，并对线虫的寿命进行评分。这项研究的结果表明，这种植物的提取物，更常被称为“蜡桃金娘”，确实显着降低秀丽隐杆线虫的寿命，增加对表皮葡萄球菌和金黄色葡萄球菌的抑制区。另外，通过化学萃取、色谱分离和光谱分析对两种化合物进行了分离和表征。这些化合物可能用于治疗细菌和线虫感染。这项研究着眼于一种常绿树木的抗菌和杀线虫作用，更具体地说是蜡桃金娘。我们的研究结果表明，桃金娘显著降低了蛔虫的寿命和某些细菌的生长。这表明，桃金娘可以改善科学家未来开发抗生素和杀线虫剂的方式。
Currently threatening the world of medicine is a growing number of antibiotic-resistant diseases. More specifically, bacteria and nematodes have gained resistance to many of the world’s leading antibiotics and nematicides, respectively, making infections more difficult to treat. Subsequently, these parasitic organisms are able to continue damaging crops and other living organisms like humans without strong interference. To help people and the environment, the development of new and novel antibiotics is vital. Previous research suggests that phytochemicals are a potential solution that will not only help inhibit bacterial growth but also reduce nematode survival. We hypothesized that Myrica cerifera, a plant often used by the Lumbee tribe to treat illness, possesses antibacterial and nematicidal properties. To answer our hypothesis, we began by collecting plant specimens to extract material for biological assays and to subsequently isolate and elucidate the structures of active components. The extract was evaluated for antibacterial properties with an agar diffusion assay and then nematicidal properties using Caenorhabditis elegans. M. cerifera extract was added onto an agar lawn at various doses, and the nematodes’ lifespans were scored. The findings of this study show that extracts of this plant, more commonly referred to as ‘wax myrtle’, do significantly decrease the lifespan of C. elegans and increase the zone of inhibition for Staphylococcus epidermidis and Staphylococcus aureus. In addition, two compounds were isolated and characterized through chemical extraction, chromatographic separation, and spectroscopic analysis. These compounds could potentially be used to treat bacterial and nematode infections. This study looks into the antibacterial and nematicidal effects of an evergreen tree, more specifically known as wax myrtle. Our results show wax myrtle significantly decreases lifespan in roundworms and the growth of certain bacteria. This suggests that wax myrtle can improve how scientists develop antibiotics and nematicides in the future.