Impact of malaria and helminth infections on immunogenicity of the human papillomavirus-16/18 AS04-adjuvanted vaccine in Tanzania
Impact of malaria and helminth infections on immunogenicity of the human papillomavirus-16/18 AS04-adjuvanted vaccine in Tanzania
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DOI：
10.1016/j.vaccine.2013.11.061
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发表时间：
2014-01-23
期刊：
影响因子：
5.5
通讯作者：
Watson-Jones, Deborah
中科院分区：
文献类型：
--
作者：
Brown, Joelle;Baisley, Kathy;Watson-Jones, Deborah
背景：撒哈拉以南非洲的地方性疟疾和蠕虫感染可以作为免疫调节剂，影响对标准免疫接种的反应。我们进行了一项队列研究，以衡量疟疾和蠕虫感染对二价HPV-16/18疫苗免疫原性的影响。方法：我们评估了疟疾和蠕虫感染之间的关联，以及298名年龄在10-25岁的坦桑尼亚女性HPV-16/18疫苗的随机对照试验中的HPV-16/18抗体应答。疟疾寄生虫病通过检查血涂片诊断，蠕虫感染分别通过检查尿液和粪便样本诊断。几何平均抗体滴度（GMT）对HPV-16/18抗体测定酶联免疫吸附试验。结果：寄生虫感染是常见的，三分之一（30.4%）的参与者有蠕虫感染和10.2%的疟疾寄生虫血症。总的来说，疫苗诱导了高HPV-16/18 GMT，并且在蠕虫或疟疾参与者中，没有证据表明HPV-16或HPV-18 GMT在第7个月或第12个月随访时降低。有一些证据表明，参与者与疟疾有增加GMT相比，那些没有maligna.Conclusions：数据显示高HPV免疫原性，无论存在疟疾和蠕虫感染。疟疾患者GMT增加的机制和意义尚不清楚。(C)2013作者由爱思唯尔有限公司出版。保留所有权利。
Background:Endemic malaria and helminth infections in sub-Saharan Africa can act as immunological modulators and impact responses to standard immunizations. We conducted a cohort study to measure the influence of malaria and helminth infections on the immunogenicity of the bivalent HPV-16/18 vaccine.Methods:We evaluated the association between malaria and helminth infections, and HPV-16/18 antibody responses among 298 Tanzanian females aged 10-25 years enrolled in a randomized controlled trial of the HPV-16/18 vaccine. Malaria parasitaemia was diagnosed by examination of blood smears, and helminth infections were diagnosed by examination of urine and stool samples, respectively. Geometric mean antibody titres (GMT) against HPV-16/18 antibodies were measured by enzyme-linked immunosorbent assay.Results:Parasitic infections were common; one-third (30.4%) of participants had a helminth infection and 10.2% had malaria parasitaemia. Overall, the vaccine induced high HPV-16/18 GMTs, and there was no evidence of a reduction in HPV-16 or HPV-18 GMT at Month 7 or Month 12 follow-up visits among participants with helminths or malaria. There was some evidence that participants with malaria had increased GMTs compared to those without malaria.Conclusions:The data show high HPV immunogenicity regardless of the presence of malaria and helminth infections. The mechanism and significance for the increase in GMT in those with malaria is unknown. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.