Eu(III)-Functionalized MOF-Based Dual-Emission Ratiometric Sensor Integrated with Logic Gate Operation for Efficient Detection of Hippuric Acid in Urine and Serum
Eu(III)-Functionalized MOF-Based Dual-Emission Ratiometric Sensor Integrated with Logic Gate Operation for Efficient Detection of Hippuric Acid in Urine and Serum
复制标题
基于 Eu(III) 功能化 MOF 的双发射比例传感器与逻辑门操作集成，可有效检测尿液和血清中的马尿酸
DOI：
10.1021/acs.inorgchem.2c03828
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发表时间：
2023
影响因子：
4.6
通讯作者：
Liming Fan
中科院分区：
文献类型：
--
作者：
Dongsheng Zhao;Wenqian Li;Rongmei Wen;Nana Lei;Wencui Li;Xin Liu;Xiutang Zhang;Liming Fan
通过引入Eu 3+离子作为二级荧光信号报告分子和传感活性位点，采用合成后包封法制备了Eu 3 +@NiMOF（Eu 3 +functionalNiMOF）双发射比率传感器，用于尿液和血清中马尿酸（HA）的检测。基于441 nm（开启）和628 nm（关闭）的两个发射信号，所制备的Eu 3 +@ NiMOF荧光传感器对HA（2.38 μM，0.42 μg·mL-1）具有更高的灵敏度和选择性，检测下限（LOD）是原始NiMOF的9.7倍。考虑到高灵敏度和可视化结果，进一步探索HA传感过程中的智能应用，构建串联组合逻辑门，借助智能手机提高实用性和便捷性。这项工作为开发基于MOF的比率传感器来检测生物标志物提供了一种有前途的方法。
With the introduction of Eu3+ions as the secondary fluorescent signal reporter and sensing active sites, a dual-emission ratiometric sensor ofEu3+@NiMOF(Eu3+functionalNiMOF) for hippuric acid (HA) detection in urine and serum was fabricatedviathe postsynthetic encapsulating strategy. Based on the two emission signals at 441 nm (turn-on) and 628 nm (turn-off), the producedEu3+@NiMOFratiometric sensor provided enhanced sensitivity, higher selectivity, and 9.7 times lower limits of detection (LOD) for the detection of HA (2.38 μM, 0.42 μg·mL–1) than that of the pristineNiMOF. Considering the high sensitivity and visualization results, further exploration of intelligent applications in the HA sensing process was carried out by constructing a tandem combinational logic gate to improve the practicability and convenience with the help of a smartphone. This work provides a promising approach for developing MOF-based ratiometric sensors to detect biomarkers.