Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction.
Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction.
复制标题
AMP 激活蛋白激酶 (AMPK) 在哺乳动物繁殖中的作用
DOI：
10.3389/fcell.2020.593005
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Yuan S
中科院分区：
文献类型：
--
作者：
Yang W;Wang L;Wang F;Yuan S
繁殖是一种需要能量的功能，只有在哺乳动物有足够的可用能量状态的情况下才会发生。代谢性疾病如神经性厌食症在临床上与生育能力下降有关。AMPK作为细胞能量稳态的主要调节因子，在有限的能量储备中被激活，以保证各种生理活动的有序进行。近年来，越来越多的证据表明AMPK通过多种机制参与生殖功能的调节。AMPK可能是一个整合中枢和外周信号的代谢传感器。本文综述了近十年来AMP活化蛋白激酶在生殖领域的作用及其作为生殖系统相关疾病药物治疗靶点的临床前研究进展。我们还强调了AMPK在生殖过程和代谢的转录调控中的新兴作用，这与生物体的能量状态和生育力密切相关。
Reproduction is an energy demanding function and only take place in case of sufficient available energy status in mammals. Metabolic diseases such as anorexia nervosa are clinically associated with reduced fertility. AMP-activated protein kinase (AMPK), as a major regulator of cellular energy homeostasis, is activated in limited energy reserves to ensure the orderly progress of various physiological activities. In recent years, mounting evidence shows that AMPK is involved in the regulation of reproductive function through multiple mechanisms. AMPK is likely to be a metabolic sensor integrating central and peripheral signals. In this review, we aim to explore the preclinical studies published in the last decade that investigate the role of AMP-activated protein kinase in the reproductive field, and its role as a target for drug therapy of reproductive system-related diseases. We also emphasized the emerging roles of AMPK in transcriptional regulation of reproduction processes and metabolisms, which are tightly related to the energy state and fertility of an organism.
登录
查看更多内容
影响因子：
4
作者：
Calder, Michele D.;Edwards, Nicole A.;Watson, Andrew J.
通讯作者：
Watson, Andrew J.
影响因子：
2.5
作者：
Bilodeau-Goeseels, Sylvie;Sasseville, Maxime;Richard, Francois J.
通讯作者：
Richard, Francois J.
影响因子：
4.1
作者：
Bertoldo, Michael J.;Guibert, Edith;Froment, Pascal
通讯作者：
Froment, Pascal
影响因子：
4.8
作者：
Abel, MH;Wootton, AN;Charlton, HM
通讯作者：
Charlton, HM
影响因子：
4.8
作者：
ADASHI, EY;RESNICK, CE;VANWYK, JJ
通讯作者：
VANWYK, JJ