How Does the Xenopus laevis Embryonic Cell Cycle Avoid Spatial Chaos?
How Does the Xenopus laevis Embryonic Cell Cycle Avoid Spatial Chaos?
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DOI：
10.1016/j.celrep.2015.06.070
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发表时间：
2015-08-04
期刊：
影响因子：
8.8
通讯作者：
Ferrell, James E., Jr.
中科院分区：
文献类型：
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作者：
Gelens, Lendert;Huang, Kerwyn Casey;Ferrell, James E., Jr.
理论研究表明，一个确定性的生化振荡器可以成为混沌时，在足够大的体积操作，并建议非洲爪蟾细胞周期振荡器操作接近这样的混沌政权。为了实验验证这一假设，我们降低了受精后钙波的速度，这被预测会产生混乱。然而，发现细胞分裂正常发展，卵发育成正常的蝌蚪。受这些实验的启发，我们进行了建模研究，以了解预测的空间混沌的先决条件。我们发现，这种类型的空间混沌需要振荡的反应动力学与短脉冲持续时间和假设，非洲爪蟾的有丝分裂出口可能是足够慢，以避免混乱。在脉冲较短的系统中，混沌可能是一个重要的危险，如心律失常，或者是一个有用的特征，如某些软体动物外壳的色素沉着。
Theoretical studies have shown that a deterministic biochemical oscillator can become chaotic when operating over a sufficiently large volume and have suggested that the Xenopus laevis cell cycle oscillator operates close to such a chaotic regime. To experimentally test this hypothesis, we decreased the speed of the post-fertilization calcium wave, which had been predicted to generate chaos. However, cell divisions were found to develop normally, and eggs developed into normal tadpoles. Motivated by these experiments, we carried out modeling studies to understand the prerequisites for the predicted spatial chaos. We showed that this type of spatial chaos requires oscillatory reaction dynamics with short pulse duration and postulated that the mitotic exit in Xenopus laevis is likely slow enough to avoid chaos. In systems with shorter pulses, chaos may be an important hazard, as in cardiac arrhythmias, or a useful feature, as in the pigmentation of certain mollusk shells.