CXC chemokines play a critical role in liver injury, recovery, and regeneration.
CXC chemokines play a critical role in liver injury, recovery, and regeneration.
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DOI：
10.1016/j.amjsurg.2009.01.025
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发表时间：
2009-09
影响因子：
3
通讯作者：
Edwards, Michael
中科院分区：
文献类型：
--
作者：
Clarke, Callisia N.;Kuboki, Satoshi;Tevar, Amit;Lentsch, Alex B.;Edwards, Michael
肝脏缺血/再灌注（I/R）损伤是创伤、肝切除手术和肝移植的主要考虑因素。尽管支持性治疗有所改善，但由于显著的组织损伤和器官功能障碍，肝I/R损伤继续对患者结局产生负面影响。CXC趋化因子被认为是肝I/R后有害炎症级联反应的关键介质，也是肝恢复和再生的重要、有益调节剂。因此，它们介导对肝细胞有益和有害作用的潜力使其成为治疗的关键靶点。在此，我们提供了一个审查的肝脏I/R损伤的炎症机制，与其他肝损伤相比，集中在不同的功能CXC趋化因子在这种反应，并提供了一个解释这个明显的矛盾。MEDLINE和PubMed CXC趋化因子是肝脏I/R炎症反应以及损伤恢复的关键介质。它们在缺血性损伤后肝块再生中的对比功能表明，这些介质途径的治疗操作应根据手术环境而不同。
Hepatic ischemia/reperfusion (I/R) injury is a principal consideration of trauma, resectional liver surgery and transplantation. Despite improvements in supportive care hepatic I/R injury continues to negatively impact patient outcomes due to significant tissue damage and organ dysfunction. CXC chemokines have been implicated as key mediators in the deleterious inflammatory cascade following hepatic I/R and also as important, beneficial regulators of liver recovery and regeneration. As such, their potential to mediate both beneficial and detrimental effects on hepatocytes makes them a key target for therapy. Herein, we provide a review of the inflammatory mechanisms of hepatic I/R injury, with a focus on the divergent functions of CXC chemokines in this response compared to other liver insults, and offer an explanation of this apparent paradox. MEDLINE and PubMed CXC chemokines are key mediators of both the inflammatory response to hepatic I/R as well as the recovery from this injury. Their contrasting functions in the regeneration of liver mass after an ischemic insult indicates that therapeutic manipulation of these mediator pathways should differ depending on the surgical milieu.
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