Catecholamine metabolizing enzymes and synthesis of dopamine in normal and grafted pituitary partes distales.
Catecholamine metabolizing enzymes and synthesis of dopamine in normal and grafted pituitary partes distales.
复制标题
正常和移植垂体远端的儿茶酚胺代谢酶和多巴胺的合成。
DOI：
10.1159/000123577
复制
发表时间：
1983
影响因子：
4.1
通讯作者：
L. M. Zieher
中科院分区：
文献类型：
--
作者：
F. Iturriza;M. Rubio;C. G. Gómez Dumm;L. M. Zieher
The presence of enzymatic activity (tyrosine hydroxylase, dopa-decarboxylase, dopamine-beta-hydroxylase, monoamine oxydase and catechol-O-methyl transferase), as well as dopamine (DA) content and DA synthesis from tyrosine and dopa, were investigated in intact rats partes distales and in grafts (both estrogenized and nonestrogenized). Counts of prolactin cells showed the following regression in the number of these cells: estrogenized grafts greater than nonestrogenized grafts greater than intrasellar intact glands. Tyrosine hydroxylase activity was not found in intact glands, but this enzyme was detected in the two types of grafts. An approximate correlation could be established between the number of prolactin cells and the diverse enzyme activities. Dopamine was not synthesized from tyrosine in intact glands, but it occurred in the transplants. However, when dopa was used, both intact and grafted glands produced dopamine. Estrogen administration decreased dopamine content in all the glands investigated. The significance of these results in relation to the physiology of the pars distalis is discussed.
