Network analysis of canine brain morphometry links tumour risk to oestrogen deficiency and accelerated brain ageing.
Network analysis of canine brain morphometry links tumour risk to oestrogen deficiency and accelerated brain ageing.
复制标题
犬脑形态测量的网络分析将肿瘤风险与雌激素缺乏和加速脑老化联系起来。
DOI：
10.1038/s41598-019-48446-0
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发表时间：
2019
影响因子：
4.6
通讯作者：
Rzechorzek NM
中科院分区：
文献类型：
--
作者：
Rzechorzek NM
结构性“脑年龄”是几种脑部疾病的有价值但复杂的生物标志物。狗是神经系统疾病建模的无与伦比的比较物，然而狗的大脑形态测量多样性带来了计算和统计方面的挑战。使用数据驱动的方法，我们探索了患者元数据、脑形态测量和神经系统疾病之间复杂的相互作用。从286张犬脑磁共振成像扫描中测量的24个形态学参数与临床参数相结合，产生9438个数据点。根据患者的大脑形态特征，采用网络分析对患者进行聚类。在拳师犬中发现了一种“老年脑”特征，即脑宽度和体积较小，同时伴有脑室增大。与未绝育的母狗相比，绝育后的母狗患脑肿瘤的风险高出11倍。尽管队列中缺乏老年拳师犬，但拳师犬和老年犬组的脑肿瘤诊断都很丰富。我们的研究结果表明，大脑的深度老化增加了狗患脑瘤的风险，并可能受到雌激素缺乏的影响——雌激素缺乏是人类痴呆症和脑瘤的一个风险因素。和人类一样，狗的大脑衰老的形态特征可能比病人的实际年龄更能预测神经疾病的风险。
Structural ‘brain age’ is a valuable but complex biomarker for several brain disorders. The dog is an unrivalled comparator for neurological disease modeling, however canine brain morphometric diversity creates computational and statistical challenges. Using a data-driven approach, we explored complex interactions between patient metadata, brain morphometry, and neurological disease. Twenty-four morphometric parameters measured from 286 canine brain magnetic resonance imaging scans were combined with clinical parameters to generate 9,438 data points. Network analysis was used to cluster patients according to their brain morphometry profiles. An ‘aged-brain’ profile, defined by a small brain width and volume combined with ventriculomegaly, was revealed in the Boxer breed. Key features of this profile were paralleled in neutered female dogs which, relative to un-neutered females, had an 11-fold greater risk of developing brain tumours. Boxer dog and geriatric dog groups were both enriched for brain tumour diagnoses, despite a lack of geriatric Boxers within the cohort. Our findings suggest that advanced brain ageing enhances brain tumour risk in dogs and may be influenced by oestrogen deficiency—a risk factor for dementia and brain tumours in humans. Morphometric features of brain ageing in dogs, like humans, might better predict neurological disease risk than patient chronological age.