Ethnicity-related variation in breast cancer risk factors.
Ethnicity-related variation in breast cancer risk factors.
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DOI：
10.1002/cncr.11014
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发表时间：
2003-01-01
期刊：
影响因子：
6.2
通讯作者：
Wilson, Jerome
中科院分区：
文献类型：
--
作者：
Bernstein, Leslie;Teal, Cayla R.;Wilson, Jerome
背景：多种因素都是乳腺癌风险的预测因素。然而，为确定这些风险因素而进行的研究很少包括非洲裔美国妇女。少数几项有足够数量非洲裔美国妇女的研究表明，非洲裔美国妇女患乳腺癌的危险因素与白色妇女相似。虽然非裔美国人和白色妇女的危险因素可能相似，但危险因素流行率的差异可能解释了发病模式的差异。方法：采用正交设计法作者回顾了非裔美国妇女乳腺癌的流行病学研究，并确定了有关非裔美国人和白色妇女危险因素患病率信息的资源。结果：在非裔美国妇女中乳腺癌危险因素的研究中存在相当大的差异。由于很少有研究包括足够数量的非洲裔美国妇女，没有确切的结论可以得出关于非洲裔美国妇女的风险估计是否不同于那些白色妇女。对乳腺癌患病率危险因素的估计表明，非洲裔美国人和白色妇女在初潮年龄、月经周期模式、出生率、哺乳史、口服避孕药使用模式、肥胖程度、绝经期激素使用频率、体力活动模式和酒精摄入量方面存在差异。结论：非裔美国妇女的危险因素概况似乎与白色妇女不同。这可能部分解释了非裔美国人在45岁之前的发病率较高，而年龄较大时的发病率较低。在一个研讨会上对这些数据的讨论强调了未来对非裔美国人乳腺癌风险研究的必要性。这项研究应该承认非裔美国妇女的异质遗产，文化信仰和文化知识。与非裔美国妇女社区和乳腺癌倡导界合作进行的研究可以受益于问卷设计和参与者招募方面的帮助。
BACKGROUND: A variety of factors are predictors of breast cancer risk. However, the studies conducted to establish these risk factors have rarely included African American women. The few studies with sufficient numbers of African-American women suggest that risk factors for breast cancer among African-American women are similar to those of white women. Although risk factors may be similar for African-American and white women, differences in the prevalence of risk factors may explain the differences in patterns of incidence. METHODS: The authors reviewed the epidemiologic studies of breast cancer among African-American women and identified resources with information regarding the prevalence of risk factors among African American and white women. RESULTS: Considerable variation exists in the studies of breast cancer risk factors among African American women. Because few studies have included sufficient numbers of African-American women, no firm conclusions can be drawn regarding whether risk estimates for African American women differ from those of white women. Estimates of the prevalence of breast cancer risk factors indicate that African American and white women differ in terms of their ages at menarche, menstrual cycle patterns, birth rates, lactation histories, patterns of oral contraceptive use, levels of obesity, frequency of menopausal hormone use, physical activity patterns, and alcohol intake. CONCLUSIONS: The risk factor profile of African-American women appears to differ from that of white women. This may explain in part, the higher incidence rates for African Americans before age 45 years and the lower incidence rates at older ages. Discussions of these data at a workshop highlighted the need for future research on breast cancer risk among African Americans. This research should acknowledge the heterogeneous heritage, cultural beliefs, and cultural knowledge of African-American women. Studies conducted in collaboration with the African-American community of women and with the breast cancer advocacy community can benefit from assistance in the design of questionnaires and recruitment of participants.