Effects of disc degeneration on neurophysiological responses during dorsoventral mechanical excitation of the ovine lumbar spine
Effects of disc degeneration on neurophysiological responses during dorsoventral mechanical excitation of the ovine lumbar spine
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DOI：
10.1016/j.jelekin.2007.02.017
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发表时间：
2008-10-01
影响因子：
2.5
通讯作者：
Harrison, Deed E.
中科院分区：
文献类型：
--
作者：
Colloca, Christopher J.;Keller, Tony S.;Harrison, Deed E.
脊柱操纵和活动的机制包括引发神经肌肉反应，但目前尚不清楚这些反应如何受到椎间盘退变的影响或改变。我们研究了正常和退化的绵羊脊柱受到与脊柱推拿疗法（SMT）一致的机械刺激（不同的力振幅和持续时间）的神经生理反应。在应用背腹侧机械激励力（设计为模拟临床常规使用的SMT力-时间谱）时，测量了L3和L4棘突附近的多裂肌激活和L4神经根的复合动作电位（CAPs）。阳性肌电反应的幅度和百分比随SMT力大小的增加而增加，但不随SMT脉冲持续时间的增加而增加，而CAP反应在短脉冲持续时间下最大。椎间盘退变与肌电图阳性反应减少（20-25%）相关，同时CAP反应增加（4.5-10.2%）。(C) 2007 Elsevier Ltd.版权所有。
Mechanisms of spinal manipulation and mobilization include the elicitation of neuromuscular responses, but it is not clear how these responses are affected or altered by disc degeneration. We studied the neurophysiological responses of the normal and degenerated ovine spine subjected to mechanical excitation (varying force amplitude and duration) consistent with spinal manipulative therapy (SMT). Needle electromyographic (EMG) multifidus muscle activation adjacent to the L3 and L4 spinous processes and compound action potentials (CAPs) of the L4 nerve roots were measured during the application of dorsoventral mechanical excitation forces designed to mimic SMT force-time profiles used routinely in clinical practice. The magnitude and percentage of positive EMG responses increased with increasing SMT force magnitude, but not SMT pulse duration, whereas CAP responses were greatest for shorter duration pulses. Disc degeneration was associated with a reduction (20-25%) in positive EMG responses, and a concomitant increase (4.5-10.2%) in CAP responses. (C) 2007 Elsevier Ltd. All rights reserved.