Study design and sample size considerations for half-life studies.
Study design and sample size considerations for half-life studies.
复制标题
半衰期研究的研究设计和样本量注意事项。
DOI：
10.1007/bf00212304
复制
发表时间：
1996
影响因子：
4
通讯作者：
Dubin,N
中科院分区：
文献类型：
--
作者：
Kim,MY;Dubin,N
Most studies on the half-lives of environmental contaminants have been based on small sample sizes and a limited number of repeated measurements. In this paper, we address issues of study design and sample size for half-life studies. Useful guidelines are provided for choosing the number of repeats and the optimal time interval between repeats for estimating an individual's half-life with a given level of precision, while minimizing the cost of the study. In addition, sample size and power considerations for studies comparing two population half-lives are investigated. An example is presented using data from a study on polychlorinated biphenyls and breast cancer.
