The chronology of oligodendrocyte differentiation in the rat optic nerve: evidence for a signaling step initiating myelination in the CNS
The chronology of oligodendrocyte differentiation in the rat optic nerve: evidence for a signaling step initiating myelination in the CNS
复制标题
大鼠视神经少突胶质细胞分化的时间顺序：中枢神经系统中启动髓鞘形成的信号传导步骤的证据
作者：
R. Colello;LR Devey;E. Imperato;U. Pott
为了确定启动轴突髓鞘形成的信号在中枢神经系统中，我们已经记载了大鼠视神经中的少突胶质细胞的分化，并将其与视神经轴突髓鞘形成的时间过程和空间梯度相关。通过使用特定于少突胶质细胞分化的不同阶段的标记物，我们发现，少突胶质细胞祖细胞，目前在整个长度的神经在出生后第2天，成熟成GC+少突胶质细胞的交叉眼进展。这种梯度沿着少突胶质细胞分化的神经继续，其中在眼睛附近的少突胶质细胞之前3天，交叉附近的少突胶质细胞表达MBP和PLP的基因和编码蛋白。虽然少突胶质细胞分化和成熟发生在一个交叉眼梯度沿着神经，视神经轴突节段附近的眼睛是髓鞘鞘前节段附近的交叉。这表明视神经轴突的髓鞘形成是由信号步骤启动的，该信号步骤独立于少突胶质细胞的分化，并且在眼睛附近比神经的交叉区域更强。通过检查提出的轴突信号，我们发现髓鞘形成的开始是独立的轴突的电活动，但可以与轴突的大小。
In order to determine the signals that initiate axon myelination in the CNS, we have chronicled the differentiation of oligodendrocytes in the rat optic nerve and related this to the time course and spatial gradient seen for optic axon myelination. By using markers specific to the varying stages of oligodendrocyte differentiation we found that oligodendrocyte progenitor cells, present throughout the length of the nerve at postnatal day 2, mature into GC+ oligodendrocytes in a chiasm to eye progression. This gradient along the nerve of oligodendrocyte differentiation continues with oligodendrocytes near the chiasm expressing the genes and encoded proteins to MBP and PLP 3 d before oligodendrocytes near the eye. Although oligodendrocyte differentiation and maturation occurs in a chiasm to eye gradient along the nerve, optic axon segments near the eye are ensheathed with myelin before segments near the chiasm. This suggests that the myelination of optic axons is initiated by a signaling step that is independent of oligodendrocyte differentiation and is stronger near the eye than the chiasm region of the nerve. By examining proposed axonal signals, we found that the onset of myelination is independent of the electrical activity of an axon but can be correlated to the size of an axon.
眼内河豚毒素对大鼠出生后视神经轴突数量减少的影响。
影响因子：
2.9
作者：
O'Leary,DD;Crespo,D;Fawcett,JW;Cowan,WM
通讯作者：
Cowan,WM