Early glandular neoplasia of the lung.
Early glandular neoplasia of the lung.
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DOI：
10.1186/rr28
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发表时间：
2000
影响因子：
5.8
通讯作者：
Westra WH
中科院分区：
文献类型：
--
作者：
Westra WH
尽管支气管癌通过化生、不典型增生和原位癌的明确顺序进展，但对肺腺肿瘤的早期进展知之甚少。特别是，至少直到最近，产生完全恶性腺癌的早期前体病变实际上一直没有被认识到。现在有几条证据表明非典型腺瘤性增生（AAH）是多步肺肿瘤发生的初始形态阶段。尽管尺寸很小，但 AAH 可以在光学显微镜水平上进行观察，并在分子遗传水平上进行表征。事实上，AAH 的遗传特征有望进一步加深我们对肺癌发展的了解，并可能有助于设计早期检测肺癌的新策略。
Although bronchogenic carcinomas progress through a very well defined sequence of metaplasia, dysplasia and carcinoma in situ, very little is known about the early progression of glandular neoplasms of the lung. In particular, the early precursor lesion from which fully malignant adenocarcinomas arise has effectively eluded recognition, at least until recently. Several lines of evidence now implicate atypical adenomatous hyperplasia (AAH) as an initial morphologic stage in multistep lung tumorigenesis. Despite its small size, AAH can be appreciated at the light microscopic level and characterized at the molecular genetic level. Indeed, the genetic characterization of AAH promises to further our understanding of lung cancer development and might facilitate the design of novel strategies for early detection of lung cancer.