Cognitive side effects of antiepileptic drugs
Cognitive side effects of antiepileptic drugs
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DOI：
10.1016/j.yebeh.2003.11.008
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发表时间：
2004-02-01
影响因子：
2.6
通讯作者：
Meador, KJ
中科院分区：
文献类型：
--
作者：
Ortinski, P;Meador, KJ
抗癫痫药物会引起中枢神经系统兴奋水平的全球性变化，并经常导致认知和行为缺陷。这些缺陷各不相同，必须在每个患者中独立考虑。已经确定了一些一致的风险因素。多药联用和高抗癫痫药物(AED)的血液水平会增加认知副作用的风险。对于一些抗癫痫药物，已经证明了不同的效果，但所有这些药物的比较数据都不完整。其他因素，如患者年龄和癫痫发作类型/频率，也可能是影响患者认知状态的重要因素。AEDs对情绪有积极或消极的影响，在选择疗程时提供了另一个考虑因素。(C)2003 Elsevier Inc.保留所有权利。
Antiepileptic drugs produce global changes in the excitation levels in the central nervous system and often lead to cognitive and behavioral deficits. These deficits vary and must be considered independently in every patient. A number of consistent risk factors have been established. Polypharmacy and high blood levels of an antiepileptic drug (AED) increase the risk of cognitive side effects. Different effects have been demonstrated for some AEDs, but comparative data are incomplete across all of them. Other factors such as patient age and type/frequency of seizures may also be important contributors to the patient's cognitive state. AEDs can have positive or negative effects on mood, providing another consideration in choosing the course of treatment. (C) 2003 Elsevier Inc. All rights reserved.