Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments.

Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments.
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DOI:
10.1007/s11899-012-0122-5
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发表时间:
2012-06
影响因子:
2.9
通讯作者:
Martinelli, Giovanni
Martinelli, Giovanni
中科院分区:
医学3区
文献类型:
--
作者:
Iacobucci, Ilaria;Papayannidis, Cristina;Lonetti, Annalisa;Ferrari, Anna;Baccarani, Michele;Martinelli, Giovanni

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在过去的十年中,基于全基因组遗传异常、结构DNA改变和序列变异的巨大技术进步使人们能够更好地了解儿童和成人B/T急性淋巴细胞白血病(ALL)的分子基础,有助于更好地认识ALL的生物异质性,并更准确地定义危险因素。重要的是,这些进展为治疗干预确定了新的潜在靶点。这篇综述将根据最近发表的文章着重于儿科和成人的细胞遗传学/分子进展。
During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T- acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles.
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