Bonelike Apatite Formation Induced on Zirconia Gel in a Simulated Body Fluid and Its Modified Solutions
Bonelike Apatite Formation Induced on Zirconia Gel in a Simulated Body Fluid and Its Modified Solutions
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模拟体液中氧化锆凝胶诱导的骨状磷灰石形成及其改进方案
DOI：
10.1111/j.1151-2916.2001.tb00955.x
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发表时间：
2004
影响因子：
3.9
通讯作者：
Takashi Nakamura
中科院分区：
文献类型：
--
作者：
M. Uchida;Hyunmin Kim;T. Kokubo;F. Miyaji;Takashi Nakamura
研究了在离子浓度与人血浆离子浓度几乎相同的模拟体液(SBF)中，在pH值升高的SBF溶液中，以及在钙离子和磷酸盐离子浓度增加的SBF溶液中，氧化锆凝胶上形成类骨磷灰石的情况。在SBF中，氧化锆凝胶表面形成了磷灰石，表明凝胶上富含的Zr-OH基团是有效的磷灰石成核中心。PH的升高以及钙离子和磷酸盐离子浓度的增加加速了磷灰石的形成，这是由于磷灰石在SBF中的离子活度积增加所致。这些结果表明，氧化锆陶瓷在活体内通过在其表面形成一层磷灰石层来表现出骨结合能力，当其表面上含有多个锆羟基时。
Formation of bonelike apatite on zirconia gel in a simulated body fluid (SBF) with ion concentrations almost equal to those in human blood plasma, in modified SBF solutions to have increased pH values, and modified SBF solutions to have increased concentrations of calcium and phosphate ions has been investigated. The zirconia gel forms apatite on its surface in SBF, indicating that Zr-OH groups, abundant on the gel, act as effective apatite nucleation centers. Apatite formation is accelerated by increases in pH and in the concentration of calcium and phosphate ions, which is explained by an increase in the ionic activity product of the apatite in the SBF. These results suggest that zirconia ceramics may exhibit a bone-bonding ability by forming an apatite layer on their surfaces in the living body when they are modified to have many Zr-OH groups on their surfaces.