Practical Issues with the Use of Stem Cells for Cancer Gene Therapy.
Practical Issues with the Use of Stem Cells for Cancer Gene Therapy.
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DOI：
10.1007/s12015-015-9605-9
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发表时间：
2015-10
影响因子：
4.8
通讯作者：
Hatefi A
中科院分区：
文献类型：
--
作者：
Nouri FS;Banerjee D;Hatefi A
在过去的十年里，基于干细胞的药物输送用于癌症治疗的势头稳步增强，因为有几项研究报告了干细胞对肿瘤的固有取向。由于这项科学仍处于早期阶段，而且有许多因素可能会显著影响干细胞的肿瘤趋向性，因此观察到了一些相互矛盾的结果。这篇综述首先检查了一些概念验证研究，这些研究证明了干细胞在癌症治疗中的潜在应用。还重点介绍了说明干细胞的肿瘤趋向性以及讨论可能影响治疗结果的技术困难的研究。讨论还强调干细胞成像/跟踪，因为它在进行可靠的剂量-反应研究和评估治疗方案的治疗结果方面发挥着至关重要的作用。在每一节中，都会突出显示与每种方法相关的优缺点，强调限制，并讨论可能的解决方案。总体目的是让读者熟悉与干细胞癌趋向性和活体跟踪相关的重要实际问题，强调不足之处，并强调需要考虑的关键因素，以便将这门科学有效地转化为临床。
Stem cell-based drug delivery for cancer therapy has steadily gained momentum in the past decade as several studies have reported stem cells' inherent tropism towards tumors. Since this science is still in its early stages and there are many factors that could significantly impact tumor tropism of stem cells, some contradictory results have been observed. This review starts by examining a number of proof-of-concept studies that demonstrate the potential application of stem cells in cancer therapy. Studies that illustrate stem cells' tumor tropism and discuss the technical difficulties that could impact the therapeutic outcome are also highlighted. The discussion also emphasizes stem cell imaging/tracking, as it plays a crucial role in performing reliable dose-response studies and evaluating the therapeutic outcome of treatment protocols. In each section, the pros and cons associated with each method are highlighted, limitations are underlined, and potential solutions are discussed. The overall intention is to familiarize the reader with important practical issues related to stem cell cancer tropism and in vivo tracking, underline the shortcomings, and emphasize critical factors that need to be considered for effective translation of this science into the clinic.