Molecular Imaging of Acute Cardiac Transplant Rejection: Animal Experiments and Prospects.
Molecular Imaging of Acute Cardiac Transplant Rejection: Animal Experiments and Prospects.
复制标题
急性心脏移植排斥的分子影像：动物实验和展望
DOI：
10.1097/tp.0000000000001780
复制
发表时间：
2017-09
期刊：
影响因子：
6.2
通讯作者：
Xie M
中科院分区：
文献类型：
--
作者：
Chen Y;Zhang L;Liu J;Zhang P;Chen X;Xie M
Abstract Acute rejection (AR) remains the biggest challenge during the first year after heart transplantation despite advances in immunosuppressive therapy. The early detection and curbing of AR are crucial to the survival of transplant recipients. However, as the criterion standard for AR, endomyocardial biopsy has several limitations because of its inherent invasiveness and morbidity. Traditional imaging techniques, such as echocardiography and cardiac magnetic resonance imaging, are of certain value for AR, but their diagnostic criteria and accuracy remain in question. Molecular imaging sheds new light on AR diagnosis because it can provide information about gene expression and the location of molecules and cells. This article reviews the latest research and applications of several typical modalities of molecular imaging used in AR and discusses their advantages and disadvantages.
