Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii
Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii
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DOI：
10.1073/pnas.0510319103
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发表时间：
2006-07-05
影响因子：
11.1
通讯作者：
Boothroyd, John C.
中科院分区：
文献类型：
--
作者：
Boyle, Jon P.;Rajasekar, Badri;Boothroyd, John C.
刚地弓形虫是顶复门的一种专性细胞内原生动物，据估计感染了全世界超过10亿人以及许多其他哺乳动物和鸟类宿主。尽管这种普遍存在，但欧洲和北美绝大多数人类感染被认为是由于只有三种基因型。使用全基因组单核苷酸多态性分析，我们已经构建了这三个线的系谱。数据表明，I型和III型分别是II型菌株与两种祖先菌株之一杂交的第二代和第一代后代。一个现存的T.弓形虫株（P89）似乎是III型的非II型亲本的现代后代，使得III型克隆型的完整谱系已知。这个简单的家谱表明，即使是一个单一的交叉可以导致一个新的克隆基因型，完全改变了性病原体的种群生物学的出现和优势。
Toxoplasma gondii, an obligate intracellular protozoan of the phylum Apicomplexa, is estimated to infect over a billion people worldwide as well as a great many other mammalian and avian hosts. Despite this ubiquity, the vast majority of human infections in Europe and North America are thought to be due to only three genotypes. Using a genome-wide analysis of single-nucleotide polymorphisms, we have constructed a genealogy for these three lines. The data indicate that types I and III are second- and first-generation offspring, respectively, of a cross between a type II strain and one of two ancestral strains. An extant T. gondii strain (P89) appears to be the modern descendant of the non-type II parent of type III, making the full genealogy of the type III clonotype known. The simplicity of this family tree demonstrates that even a single cross can lead to the emergence and dominance of a new clonal genotype that completely alters the population biology of a sexual pathogen.