Neuropeptide S: A neuropeptide promoting arousal and anxiolytic-like effects
Neuropeptide S: A neuropeptide promoting arousal and anxiolytic-like effects
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DOI：
10.1016/j.neuron.2004.08.005
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发表时间：
2004-08-19
期刊：
影响因子：
16.2
通讯作者：
Civelli, O
中科院分区：
文献类型：
--
作者：
Xu, YL;Reinscheid, RK;Civelli, O
唤醒和焦虑是涉及复杂神经回路和多种神经化学成分的行为反应。在这里，我们报告了一种神经肽，神经肽 S (NPS)，可以有效调节觉醒，也可以调节焦虑。 NIPS 通过激活其同源受体 (NPSR) 并诱导细胞内 Ca2+ 动员来发挥作用。 NPSR mRNA广泛分布于大脑中，包括杏仁核和中线丘脑核。 NPS 的中枢给药可增加小鼠的运动活动，并减少大鼠的反常 (REM) 睡眠和慢波睡眠。进一步证明，NPS 可以在暴露于四种不同压力模式的小鼠中产生类似抗焦虑的作用。有趣的是，NPS 在位于蓝斑 (LC) 和巴灵顿核之间的先前未定义的细胞簇中表达。这些结果表明 NIPS 可能是一种新的唤醒和焦虑调节剂。他们还表明，LC 区域包含表达不同刺激性神经递质的不同细胞核。
Arousal and anxiety are behavioral responses that involve complex neurocircuitries and multiple neurochemical components. Here, we report that a neuropeptide, neuropeptide S (NPS), potently modulates wakefulness and could also regulate anxiety. NIPS acts by activating its cognate receptor (NPSR) and inducing mobilization of intracellular Ca2+. The NPSR mRNA is widely distributed in the brain, including the amygdala and the midline thalamic nuclei. Central administration of NPS increases locomotor activity in mice and decreases paradoxical (REM) sleep and slow wave sleep in rats. NPS was further shown to produce anxiolytic-like effects in mice exposed to four different stressful paradigms. Interestingly, NPS is expressed in a previously undefined cluster of cells located between the locus coeruleus (LC) and Barrington's nucleus. These results indicate that NIPS could be a new modulator of arousal and anxiety. They also show that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters.