A score based on screening tests to differentiate mild cognitive impairment from subjective memory complaints
A score based on screening tests to differentiate mild cognitive impairment from subjective memory complaints
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DOI：
10.4081/ni.2013.e16
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发表时间：
2013-01-01
影响因子：
3
通讯作者：
Dozzi Brucki, Sonia Maria
中科院分区：
文献类型：
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作者：
de Gobbi Porto, Fabio Henrique;Spindola, Livia;Dozzi Brucki, Sonia Maria
区分轻度认知障碍（MCI）患者和主观记忆抱怨者（SMC）并不容易。使用筛查认知工具进行评估至关重要，特别是在大多数患者就诊的初级保健中。本研究的目的是评估筛查认知测试的诊断准确性，并提出一个评分来自筛查测试。采用简易精神状态检查（MMSE）和简易认知成套测验（BCB）对有记忆障碍的老年受试者进行评估。我们在MMSE中增加了两个延迟回忆（延迟回忆和迟发延迟回忆，LDR），以及字母P流畅性（LPF）的音素流畅性测试。根据这些测试创建评分。诊断是根据临床共识和神经心理学测试作出的。使用受试者工作特征曲线分析来确定曲线下面积（AUC）、每个测试的灵敏度和特异性以及最终拟定评分。MMSE、LDR、LPF和延迟回忆的BCB评分组间差异有统计学意义（P=0.000、0.03、0.001和0.01）。敏感性、特异性和AUC分别为MMSE：64%、79%和0.75（截止值
It is not easy to differentiate patients with mild cognitive impairment (MCI) from subjective memory complainers (SMC). Assessments with screening cognitive tools are essential, particularly in primary care where most patients are seen. The objective of this study was to evaluate the diagnostic accuracy of screening cognitive tests and to propose a score derived from screening tests. Elderly subjects with memory complaints were evaluated using the Mini Mental State Examination (MMSE) and the Brief Cognitive Battery (BCB). We added two delayed recalls in the MMSE (a delayed recall and a late- delayed recall, LDR), and also a phonemic fluency test of letter P fluency (LPF). A score was created based on these tests. The diagnoses were made on the basis of clinical consensus and neuropsychological testing. Receiver operating characteristic curve analyses were used to determine area under the curve (AUC), the sensitivity and specificity for each test separately and for the final proposed score. MMSE, LDR, LPF and delayed recall of BCB scores reach statistically significant differences between groups (P=0.000, 0.03, 0.001 and 0.01, respectively). Sensitivity, specificity and AUC were MMSE: 64%, 79% and 0.75 (cut off