Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message.
Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message.
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DOI：
10.3390/ncrna7010021
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发表时间：
2021-03-11
期刊：
影响因子：
4.3
通讯作者：
Ladomery M
中科院分区：
文献类型：
--
作者：
Pisignano G;Ladomery M
选择性剪接是一个高度微调的调控过程，是真核生物蛋白质组多样性的主要驱动力之一。绝大多数人类多外显子基因以细胞类型和组织特异性方式选择性剪接，并且选择性剪接中的缺陷可以显著改变RNA和蛋白质功能并导致疾病。真核基因组也被强烈转录成长和短的非编码RNA，其占整个转录组的90%。多年来，lncRNA作为调节包括选择性剪接在内的细胞过程的重要参与者受到了相当大的关注。在这篇综述中，我们专注于最近的发现，显示如何lncRNA的贡献显着的调节选择性剪接，并探讨他们是如何能够塑造一组不同的剪接异构体的表达，通过几种机制。随着越来越多的lncRNA被发现和表征，lncRNA对可变剪接调控的贡献可能会显着增长。
Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is alternatively spliced in a cell type- and tissue-specific manner, and defects in alternative splicing can dramatically alter RNA and protein functions and lead to disease. The eukaryotic genome is also intensively transcribed into long and short non-coding RNAs which account for up to 90% of the entire transcriptome. Over the years, lncRNAs have received considerable attention as important players in the regulation of cellular processes including alternative splicing. In this review, we focus on recent discoveries that show how lncRNAs contribute significantly to the regulation of alternative splicing and explore how they are able to shape the expression of a diverse set of splice isoforms through several mechanisms. With the increasing number of lncRNAs being discovered and characterized, the contribution of lncRNAs to the regulation of alternative splicing is likely to grow significantly.
影响因子：
4
作者：
Flynn, Ryan A.;Chang, Howard Y.
通讯作者：
Chang, Howard Y.