A new paradigm in dermatopharmacokinetics - Confocal Raman spectroscopy
A new paradigm in dermatopharmacokinetics - Confocal Raman spectroscopy
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DOI：
10.1016/j.ijpharm.2013.01.036
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发表时间：
2013-02-28
影响因子：
5.8
通讯作者：
Lane, M. E.
中科院分区：
文献类型：
--
作者：
Mateus, R.;Abdalghafor, H.;Lane, M. E.
共聚焦拉曼光谱（CRS）是一种用于测定角质层厚度和分析内源性皮肤成分的新方法。然而，迄今为止，这种技术在体内探测药物处置方面的效用尚未得到探索。在本文中，我们报告了使用CRS来调查布洛芬在使用简单配方后的命运，这些配方以前是用胶带剥离法研究的。以丙二醇（PG）和丙二醇/水（PG/H2O）溶液制备布洛芬。然后将这些配方应用于人类志愿者前臂的掌侧。结果证实，布洛芬在角质层中的分布曲线与先前发表的胶带剥离实验数据相当。我们建议CRS作为一种非侵入性的方法来评估局部药物制剂的皮肤药代动力学。(C) 2013 Elsevier b.v.版权所有
Confocal Raman spectroscopy (CRS) is a novel approach which has been used to determine stratum corneum thickness and to profile endogenous skin components. However, the utility of this technique for probing drug disposition in vivo has not been explored to date. In this paper we report the use of CRS to investigate the fate of ibuprofen after application from simple formulations which were previously investigated using the tape-stripping approach. Ibuprofen was prepared in propylene glycol (PG) and propylene glycol/water (PG/H2O) solutions. The formulations were then applied to the volar aspect of the forearm of human volunteers. The results confirmed that ibuprofen distribution profiles in the stratum corneum were comparable to previously published data from tape stripping experiments. We propose CRS as a non-invasive method for dermatopharmacokinetic evaluation of topical pharmaceutical formulations. (C) 2013 Elsevier B. V. All rights reserved.