How receptors talk to trimeric G proteins
How receptors talk to trimeric G proteins
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DOI：
10.1016/s0955-0674(97)80054-3
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发表时间：
1997-04-01
影响因子：
7.5
通讯作者：
Bourne, HR
中科院分区：
文献类型：
--
作者：
Bourne, HR
在激素和感觉刺激的刺激下，蛇纹石受体促进与三聚体G蛋白a亚单位结合的GDP的释放，并被GTP取代。最近的研究已经开始确定受体和G蛋白的大小、形状和相对取向，它们相互作用的表面，以及这两组分子的构象变化，这些分子是受体催化的鸟嘌呤-核苷酸交换的基础。
Stimulated by hormones and sensory stimuli, serpentine receptors promote the release of GDP that is bound to the a subunit of trimeric G proteins and its replacement by GTP. Recent investigations have begun to define the sizes, shapes, and relative orientations of receptors and G proteins, ?he surfaces through which they interact with one another, and conformational changes in both sets of molecules that underlie receptor-catalyzed guanine-nucleotide exchange.