Nanodiamond-PMO for two-photon PDT and drug delivery
Nanodiamond-PMO for two-photon PDT and drug delivery
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DOI：
10.1039/c6tb01915c
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发表时间：
2016-01-01
影响因子：
7
通讯作者：
Durand, Jean-Olivier
中科院分区：
文献类型：
--
作者：
Jimenez, Chiara Mauriello;Knezevic, Nikola Z.;Durand, Jean-Olivier
在这篇文章中，我们强调纳米金刚石（ND），这是封装在周期性介孔有机硅纳米粒子（PMO），并能够产生活性氧物种的光动力学应用后，双光子激发（TPE）的属性。ND@PMO纳米颗粒通过各种技术进行表征，然后加载抗癌药物阿霉素。药物的释放是pH敏感的，并且当癌细胞与负载阿霉素的ND@PMO孵育并在800 nm处用双光子激发照射时，观察到协同的癌细胞杀伤效应。
In this article, we highlight the properties of nanodiamonds (ND), which were encapsulated in periodic mesoporous organosilica nanoparticles (PMO) and were able to generate reactive oxygen species for photodynamic applications upon two-photon excitation (TPE). The ND@PMO nanoparticles were characterized by various techniques and were then loaded with the anti-cancer drug doxorubicin. The release of the drug was pH sensitive and a synergistic cancer cell killing effect was observed when cancer cells were incubated with doxorubicin-loaded ND@PMO and irradiated with two-photon excitation at 800 nm.