Fibrinolytic poly(dimethyl siloxane) surfaces.
Fibrinolytic poly(dimethyl siloxane) surfaces.
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DOI：
10.1002/mabi.200800014
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发表时间：
2008-09
影响因子：
4.6
通讯作者：
Hong Chen;Liang Wang;Yanxia Zhang;Dan Li;W. G. McClung;Michael A. Brook;H. Sheardown;J. Brash
中科院分区：
文献类型：
--
作者：
Hong Chen;Liang Wang;Yanxia Zhang;Dan Li;W. G. McClung;Michael A. Brook;H. Sheardown;J. Brash
PDMS 表面经过修饰，具有对非特异性蛋白质吸附的抵抗力和凝块溶解特性。使用水接触角测量、ATR FT-IR 光谱和 XPS 研究了表面的性质和化学成分。通过测量缓冲液中放射性标记的纤维蛋白原的摄取来评估 PEG 成分抑制非特异性蛋白质吸附的能力。研究了人血浆中纤溶酶原对各种表面的吸附。体外实验表明，具有游离ε-氨基的赖氨酸固定表面在暴露于血浆和组织纤溶酶原激活剂后能够溶解纤维蛋白凝块。 【图：见正文】。
PDMS surfaces have been modified to confer both resistance to non-specific protein adsorption and clot lyzing properties. The properties and chemical compositions of the surfaces have been investigated using water contact angle measurements, ATR FT-IR spectroscopy, and XPS. The ability of the PEG component to suppress non-specific protein adsorption was assessed by measurement of radiolabeled fibrinogen uptake from buffer. The adsorption of plasminogen from human plasma to the various surfaces was studied. In vitro experiments demonstrated that lysine-immobilized surfaces with free epsilon-amino groups were able to dissolve fibrin clots, following exposure to plasma and tissue plasminogen activator. [Figure: see text].