Cohort Profile: The Framingham Heart Study (FHS): overview of milestones in cardiovascular epidemiology
Cohort Profile: The Framingham Heart Study (FHS): overview of milestones in cardiovascular epidemiology
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DOI：
10.1093/ije/dyv337
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发表时间：
2015-12-01
影响因子：
7.7
通讯作者：
Vasan, Ramachandran S.
中科院分区：
文献类型：
--
作者：
Tsao, Connie W.;Vasan, Ramachandran S.
心脏病研究（FHS）进行了开创性的研究，定义了心血管疾病（CVD）的风险因素，并在过去的五十年中从根本上塑造了CVD预防的公共卫生指南。1948年发起的原始队列的成功为预防心脏病学的进一步流行病学研究铺平了道路。由于敏锐的观察表明共同的家庭因素在CVD的发展中的作用，1971年FHS开始招募第二代队列，包括原始队列的子女和子女的配偶。在2002年，第三代队列，包括原始队列的孙子，开始进一步探索遗传贡献CVD更深入。此外，由于上述三代FHS参与者中欧洲血统的白色个体占主导地位，心脏研究分别于1994年和2003年招募了OMNI 1和OMNI 2队列，旨在反映Fracket镇目前更大的种族和民族多样性。自研究开始以来，大约每2-4年对所有FHS队列进行一次检查。在这些定期的心脏研究检查中，我们获得病史，并进行心血管重点体检，12导联心电图，血液和尿液样本测试和其他反映亚临床疾病负担的心血管成像研究。FHS自成立以来一直沿着心血管科学和流行病学研究的前沿。参与者研究现在还包括心血管成像、血清和尿液生物标志物、遗传学/基因组学、蛋白质组学、代谢组学和社交网络的研究。已经建立了许多辅助研究，将表型扩展到包括多个器官系统，包括肺、脑、骨和脂肪库等。虽然FHS最初的设想和设计是为了研究心血管疾病的流行病学，但多年来它已经发展到惊人的广度和深度，在广泛的人类疾病的流行病学研究中具有更大的影响。FHS欢迎使用现有或新收集的数据进行研究合作。有关研究申请提交和审查程序的详细信息，请访问[http：//www.framinghamheartstudy.org/researchers/index.php]。
The Framingham Heart Study (FHS) has conducted seminal research defining cardiovascular disease (CVD) risk factors and fundamentally shaping public health guidelines for CVD prevention over the past five decades. The success of the Original Cohort, initiated in 1948, paved the way for further epidemiological research in preventive cardiology. Due to the keen observations suggesting the role of shared familial factors in the development of CVD, in 1971 the FHS began enroling the second generation cohort, comprising the children of the Original Cohort and the spouses of the children. In 2002, the third generation cohort, comprising the grandchildren of the Original Cohort, was initiated to additionally explore genetic contributions to CVD in greater depth. Additionally, because of the predominance of White individuals of European descent in the three generations of FHS participants noted above, the Heart Study enrolled the OMNI1 and OMNI2 cohorts in 1994 and 2003, respectively, aimed to reflect the current greater racial and ethnic diversity of the town of Framingham. All FHS cohorts have been examined approximately every 2-4 years since the initiation of the study. At these periodic Heart Study examinations, we obtain a medical history and perform a cardiovascular-focused physical examination, 12-lead electrocardiography, blood and urine samples testing and other cardiovascular imaging studies reflecting subclinical disease burden.The FHS has continually evolved along the cutting edge of cardiovascular science and epidemiological research since its inception. Participant studies now additionally include study of cardiovascular imaging, serum and urine biomarkers, genetics/genomics, proteomics, metabolomics and social networks. Numerous ancillary studies have been established, expanding the phenotypes to encompass multiple organ systems including the lungs, brain, bone and fat depots, among others. Whereas the FHS was originally conceived and designed to study the epidemiology of cardiovascular disease, it has evolved over the years with staggering expanded breadth and depth that have far greater implications in the study of the epidemiology of a wide spectrum of human diseases. The FHS welcomes research collaborations using existing or new collection of data. Detailed information regarding the procedures for research application submission and review are available at [http://www.framinghamheartstudy.org/researchers/index.php].