Clinicopathological features and medical management of early gastric cancer
Clinicopathological features and medical management of early gastric cancer
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DOI：
10.1016/j.amjsurg.2007.02.025
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发表时间：
2008-02-01
影响因子：
3
通讯作者：
Hanazaki, Kazuhiro
中科院分区：
文献类型：
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作者：
Okabayashi, Takehiro;Kobayashi, Michiya;Hanazaki, Kazuhiro
背景：由于内窥镜技术和设备的进步，早期胃癌(EGC)的检测在全球范围内都有所增加。本研究的目的是比较有无淋巴结转移的早期胃癌患者的临床病理表现。方法：收集1981~2002年在高知医学院接受手术治疗的440例早期胃癌患者的临床资料。多因素分析发现有4个独立的淋巴结转移危险因素：(1)黏膜下侵犯；(2)肿瘤直径大于3.5 cm；(3)有血管侵犯；(4)有淋巴渗透。结论：对于肿瘤大小在1 cm到3.5 cm之间的患者，我们建议首先在内窥镜下切除，如果肿瘤有血管侵犯或淋巴渗透，应考虑再次手术切除。(C)2008 Excerpta Medica Inc.版权所有。
Background: The detection of early gastric carcinoma (EGc) has increased worldwide due to advances in endoscopic techniques and equipment. The aim of the current study was to compare the clinicopathological findings of patients with and without lymph node metastasis.Methods: A total of 440 cases of early gastric carcinoma in patients who underwent surgical procedures between 1981 and 2002 at Kochi Medical School were studied.Results: Lymph node metastasis was observed in 38-patients (8.6%) with EGC. Multivariate analysis identified 4 independent risk factors of lymph node metastasis: (1) submucosal invasion; (2) tumor diameter greater than 3.5 cm; (3) the presence of vascular invasion; and (4) the presence of lymphatic permeation.Conclusion: For patients with tumor size between 1 cm and 3.5 cm we would recommend endoscopic resection initially, with a consideration for additional surgical resection if microscopic vascular invasion or lymphatic permeation is demonstrated. (C) 2008 Excerpta Medica Inc. All rights reserved.