Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells
Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells
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DOI：
10.1016/j.immuni.2015.07.016
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发表时间：
2015-08-18
期刊：
影响因子：
32.4
通讯作者：
Karjalainen, Klaus
中科院分区：
文献类型：
--
作者：
Sheng, Jianpeng;Ruedl, Christiane;Karjalainen, Klaus
巨噬细胞在体内平衡和疾病期间的解剖位置和功能特化方面是最多样化的细胞群之一。尽管在不同的命运定位模型中已经显示，一些存在于成体组织中的巨噬细胞已经在胎儿发育期间建立，但它们的确切起源仍在争论中。在目前的研究中，我们开发了一种基于Kit基因座的命运作图菌株，这使我们能够重新解决“起源”问题。通过在胎儿发育期间或成年小鼠中的几个时间点诱导前体中的标记，将来自各种成年组织的不同类型的巨噬细胞追踪到它们的胎儿或成年来源。我们表明，所有成年巨噬细胞（驻留或浸润）都是经典造血干细胞（HSC）的后代，但小胶质细胞和部分表皮朗格汉斯细胞除外，它们是卵黄囊（YS）衍生的。
Macrophages are one of the most diverse cell populations in terms of their anatomical location and functional specialization during both homeostasis and disease. Although it has been shown in different fate mapping models that some macrophages present in adult tissues are already established during fetal development, their exact origins are still under debate. In the current study, we developed a fate mapping strain, based on the Kit locus, which allowed us to readdress "the origins'' question. Different types of macrophages from various adult tissues were traced to their fetal or adult sources by inducing labeling in precursors at several time points either during fetal development or in adult mice. We show that all adult macrophages, resident or infiltrating, are progenies of classical hematopoietic stem cells (HSC) with the exception of microglia and, partially epidermal Langerhans cells, which are yolk sac (YS)-derived.