Immunologic reactivity of lymphoid cells in tumors.
Immunologic reactivity of lymphoid cells in tumors.
复制标题
肿瘤中淋巴细胞的免疫反应性。
DOI：
--
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Haskill
中科院分区：
文献类型：
--
作者：
R. Herberman;H. Holden;L. Varesio;T. Taniyama;P. Puccetti;H. Kirchner;J. Gerson;S. White;Y. Keisari;J. Haskill
已经有许多针对肿瘤的免疫反应的研究，几乎所有这些研究都集中在血液或脾脏中的反应性。从这些研究中可以清楚地看出，多种效应细胞和免疫功能类型可能参与抗肿瘤反应。人们特别关注可能对肿瘤细胞具有直接细胞毒性或在肿瘤抗原刺激后增殖或产生淋巴因子的T细胞。然而，可能涉及并需要考虑其他效应机制。其中包括 B 细胞，它可以产生直接影响肿瘤细胞或与 K 细胞或巨噬细胞相互作用的抗体，从而介导抗体依赖性细胞介导的细胞毒性；巨噬细胞和单核细胞，具有自发细胞毒性或可被激活以对肿瘤细胞产生细胞毒性；和自然杀伤（NK）细胞，这是一种对肿瘤细胞具有自发细胞毒性反应的淋巴细胞亚群。
There have been many studies of immune responses against tumors and almost all of these have focused on the reactivity in the blood or spleen. From such studies, it has become clear that a wide variety of effector cells and types of immune functions may be involved in antitumor responses. Particular attention has been directed toward T cells that may be directly cytotoxic against tumor cells or may proliferate or produce lymphokines upon stimulation with tumor antigens. However, other effector mechanisms may be involved and need to be considered. These include B cells, which can produce antibodies that affect tumor cells directly or that interact with K cells or macrophages and thereby mediate antibody-dependent cell-mediated cytotoxicity; macrophages and monocytes, which are spontaneously cytotoxic or can be activated to become cytotoxic against tumor cells; and natural killer (NK) cells, a subpopulation of lymphocytes with spontaneous cytotoxic reactivity against tumor cells.