Synthetic study of manzamine B: synthesis of the tricyclic central core by an asymmetric Diels-Alder and RCM strategy
Synthetic study of manzamine B: synthesis of the tricyclic central core by an asymmetric Diels-Alder and RCM strategy
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DOI：
10.1016/j.tetlet.2006.12.029
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发表时间：
2007-02-12
影响因子：
1.8
通讯作者：
Nishida, Atsushi
中科院分区：
文献类型：
--
作者：
Matsumura, Tomoaki;Akiba, Masakatsu;Nishida, Atsushi
通过不对称Diels-Alder反应和RCM策略成功合成了三环Manzarnine B核心。 Cr-salen-F 络合物被发现是氨基二烯与杂环亲二烯体 DA 反应中最有效的催化剂，其 ce 高达 97%。在 RCM 构建 11 元环时，首先是格拉布斯猫。具有更好的立体选择性。 (c) 2006 Elsevier Ltd. 保留所有权利。
Tricyclic core of manzarnine B was successfully synthesized through asymmetric Diels-Alder reaction and RCM strategy. Cr-salen-F complex was found to be the most effective catalyst in DA reaction of aminodienes with heterocyclic dienophiles to give up to 97% ce. In the construction of 11-membered ring by RCM, first-Grubbs cat. gave better stereoselectivity. (c) 2006 Elsevier Ltd. All rights reserved.