LDL-cholesterol and HDL-cholesterol concentrations decrease during the day
LDL-cholesterol and HDL-cholesterol concentrations decrease during the day
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DOI：
10.1258/0004563021901946
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发表时间：
2002-05-01
影响因子：
2.2
通讯作者：
Okada, M
中科院分区：
文献类型：
--
作者：
Miida, T;Nakamura, Y;Okada, M
背景低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的均相测定具有高度准确性，几乎不受甘油三酯的干扰。使用这些方法，我们测量了餐后LDL-C和HDL-C。早期的研究2表明，LDL-C在餐后降低。方法为了阐明LDL-C和HDL-C是否在白天显著降低，我们使用均相测定法测定了正常冠状动脉受试者的LDL-C和HDL-C的每日曲线（N; n = 10），和冠状动脉疾病受试者结果两组患者早餐后至午夜LDL-C、HDL-C均较早餐前显著降低。第二天早上，他们回到了基线水平。LDL-C的平均降低在N中为0.09-0.13 mmol/L，在N中为0.05-0 mmol/L。20 mmol/L，HDL-C为0。02-0（.）06 mmol/L的N和0（.）00-0（.）结论LDL-C和HDL-C在一天内明显下降。
Background Homogenous assays for LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) are highly accurate, with little interference from triglyceride. Using these methods, we measured postprandial LDL-C and HDL-C. Earlier studies 2 suggested a postprandial decrease in LDL-C.Methods To elucidate whether LDL-C and HDL-C decrease significantly during the day, we determined daily profiles of LDL-C and HDL-C using homogeneous assays in subjects with normal coronary arteries (N; n = 10), and subjects with coronary artery disease (CAD; n = 23).Results In both groups, LDL-C and HDL-C were significantly lower from after breakfast until midnight than they were before breakfast. The next morning, they returned to baseline levels. The mean reduction in LDL-C was 0.09-0.13 mmol/L in N and 0.05-0(.)20 mmol/L in CAD, while that in HDL-C was 0(.)02-0(.)06 mmol/L in N and 0(.)00-0(.)05 mmol/L in CAD.Conclusion LDL-C and HDL-C decrease significantly over the course of the day.