Muscle strength in type 2 diabetes
Muscle strength in type 2 diabetes
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DOI：
10.2337/diabetes.53.6.1543
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发表时间：
2004-06-01
期刊：
影响因子：
7.7
通讯作者：
Jakobsen, J
中科院分区：
文献类型：
--
作者：
Andersen, H;Nielsen, S;Jakobsen, J
2型糖尿病的运动功能在很大程度上是未知的。在36例2型糖尿病患者和36例对照组中，在性别、年龄、体重、身高和体力活动方面相匹配，采用等速测力法评估肘、腕、膝和踝关节的屈肌和伸肌力量。神经病变的程度通过临床评分、神经传导研究和定量感觉测试来确定。最后，将所有结果相加以获得神经病变等级总和评分（NRSS）。同时评估肾病程度和视网膜状况。糖尿病患者踝关节屈肌和伸肌肌力分别下降17%和14%（P < 0.02和P < 0.03）。在膝关节，伸肌和屈肌的力量分别降低了7%（NS）和14%（P < 0.05）。在手肘和手腕处，肌肉力量得以保留。NRSS与踝关节肌力（r =-0.45，P < 0.01）和膝关节肌力（r =-0.42，P < 0.02）相关。多元回归分析显示，NRSS而非肾病或视网膜病变的程度与踝关节和膝关节的力量有关。总之，2型糖尿病患者踝关节和膝关节肌无力可能与周围神经病变的存在和严重程度有关。
Motor function in type 2 diabetes is largely unknown. In 36 type 2 diabetic patients and in 36 control subjects matched for sex, age, weight, height, and physical activity, strength of flexors and extensors at elbow, wrist, knee, and ankle was assessed at isokinetic dynamometry. The degree of neuropathy was determined by clinical scores, nerve conduction studies, and quantitative sensory testing. Eventually, all results were summed to obtain a neuropathy rank-sum score (NRSS). The degree of nephropathy and retinal condition were also evaluated. Diabetic patients had a 17 and 14% reduction of strength of ankle flexors (P < 0.02) and ankle extensors (P < 0.03), respectively. At the knee, strength of extensors and flexors was reduced by 7% (NS) and 14% (P < 0.05), respectively. At the elbow and wrist, muscle strength was preserved. The NRSS was related to the strength at the ankle (r = -0.45, P < 0.01) and knee (r = -0.42, P < 0.02). Following multiple regression analysis, the NRSS but not the degree of nephropathy or retinopathy was related to strength at the ankle and knee. In conclusion, type 2 diabetic patients may have muscle weakness at the ankle and knee related to presence and severity of peripheral neuropathy.