Neural correlates of eye blinking; improved by simultaneous fMRI and EOG measurement
Neural correlates of eye blinking; improved by simultaneous fMRI and EOG measurement
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DOI：
10.1016/j.neulet.2005.01.077
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发表时间：
2005-06-10
影响因子：
2.5
通讯作者：
Park, HW
中科院分区：
文献类型：
--
作者：
Yoon, HW;Chung, JY;Park, HW
使用功能磁共振成像技术可以研究健康人眨眼的神经相关因素。然而，之前大多数研究的焦点都集中在故意眨眼上。本研究的目的是在功能磁共振成像（fMRI）数据采集过程中，借助EOG测量来研究自发眨眼的神经相关性。去除EOG信号中的脉冲伪影后，EOG波形清晰地显示眨眼，与MRI扫描仪外测量的结果相当。在此检测的基础上，每个眨眼事件都可以作为事件相关fMRI的时间线索。在比较中，我们还研究了眨眼抑制的神经相关因素。根据大脑的激活模式，在两种情况下，双侧海马旁、视觉皮层的激活都是常见的。观察到与眨眼抑制相对应的中央前回和与自发眨眼相对应的右侧内侧额回的额外激活。基于这些结果，我们得出结论，内侧额回负责自发眨眼，而中央前激活似乎与眨眼抑制有关。2005爱思唯尔爱尔兰有限公司版权所有。
Neural correlates of eye blink in healthy human subjects can be investigated using functional magnetic resonance imaging. However, the focus of most previous studies has been on intentional eye blinking. The goal of the present study was to examine the neural correlates of spontaneous eye blinking with the help of EOG measurements during data acquisition of fMRI. After the removal of the pulse artifact in the EOG signal, EOG waveform clearly indicates eye blinking, which was equivalent to those measured outside of the MRI scanner. On the basis of this detection, each blinking event can be used as a temporal cue for the event-related fMRI. In a comparison, we also investigated the neural correlates of blink inhibition. Based on the brain activation pattern, the activation of the bilateral parahippocampal, the visual cortex was commonly observed for both conditions. The additional activation of the precentral gyrus, corresponding to blink inhibition, and the right medial frontal gyrus, corresponding to spontaneous blinking were observed. Based on these results, we conclude that the medial frontal gyrus is responsible for spontaneous eye blinking, whereas precentral activation appears to be related to blink inhibition. (c) 2005 Elsevier Ireland Ltd. All rights reserved.