Cobalt-55 positron emission tomography of ipsilateral thalamic and crossed cerebellar hypometabolism after supratentorial ischaemic stroke
Cobalt-55 positron emission tomography of ipsilateral thalamic and crossed cerebellar hypometabolism after supratentorial ischaemic stroke
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DOI：
10.1159/000015894
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发表时间：
1999-01-01
影响因子：
2.9
通讯作者：
Korf, J
中科院分区：
文献类型：
--
作者：
De Reuck, J;Stevens, H;Korf, J
钴-55(Co-55)是一种正电子发射断层扫描(PET)示踪剂，用于显示脑损伤，可能与钙介导的过程有关。Co-55蓄积程度与卒中患者脑缺血的严重程度相关。大脑中动脉(MCA)梗塞后发生的同侧丘脑低代谢(ITH)和交叉性小脑低代谢(CCH)是否仅代表这些偏远区域的代谢抑制，还是可以导致结构性损害，仍是一个有争议的问题。本研究调查在大脑中动脉梗死后的ITH和CCH中，是否可以通过PET证实Co-55内流的增加。大约一半的ITH和CCH患者分别在同侧丘脑和对侧小脑半球有显著程度的Co-55摄取。在入院时有严重卒中体征和临床预后差的患者中观察到，并与幕上脑梗塞内Co-55流入的程度有很好的相关性。本研究表明，MCA梗死后ITH和CCH可以代表卒中后第2周发生在这些偏远地区的结构损害。
Cobalt-55 (Co-55) is a positron emission tomography (PET) tracer used to demonstrate brain damage, possibly associated to calcium-mediated processes. The degree of Co-55 accumulation correlates with the severity of ischaemia in stroke patients. It is still a matter of debate whether ipsilateral thalamic hypometabolism (ITH) and crossed cerebellar hypometabolism (CCH), occurring after middle cerebral artery (MCA) infarcts, represent only a metabolic depression of these remote regions or can lead to structural damage. The present study investigates whether an increased Co-55 influx can be demonstrated with PET in ITH and CCH after MCA infarcts. About half of the patients with ITH and CCH had a significant degree of Co-55 uptake in, respectively, the ipsilateral thalamus and the contralateral cerebellar hemisphere. It was observed in patients with severe signs of stroke on admission and poor clinical outcome, and correlated well with the degree of Co-55 influx within the supratentorial infarct, The present study demonstrates that ITH and CCH after MCA infarction can represent structural damage in these remote areas that occurs during the second week after stroke onset.