Primary Amines as Directing Groups in the Ru-Catalyzed Synthesis of Isoquinolines, Benzoisoquinolines, and Thienopyridines
Primary Amines as Directing Groups in the Ru-Catalyzed Synthesis of Isoquinolines, Benzoisoquinolines, and Thienopyridines
复制标题
DOI：
10.1021/jo400344m
复制
发表时间：
2013-06-07
影响因子：
3.6
通讯作者：
Urriolabeitia, Esteban P.
中科院分区：
文献类型：
--
作者：
Villuendas, Pedro;Urriolabeitia, Esteban P.
以钌为催化剂，通过氧化偶联反应合成了在芳香环或杂芳香环的不同位置上具有多种取代基的异喹啉、苯并异喹啉、噻吩并[3，2-c]吡啶和稠合杂芳基[2，3-c]吡啶。所有的苄胺和杂环都有未保护的伯胺作为有效的导向基团。
Isoquinolines, benzoisoquinolines, thieno[3,2-c]pyridines and fused heteroaryl[2,3-c] pyridines, with a wide variety of substituents at different positions of the aromatic or heteroaromatic rings, have been synthesized by Ru-catalyzed oxidative coupling of a broad range of benzylamines or heterocycles with internal alkynes. All benzylamines and heterocycles have unprotected primary amines as efficient directing groups.