Neural substrates of accurate perception of time duration: A functional magnetic resonance imaging study
Neural substrates of accurate perception of time duration: A functional magnetic resonance imaging study
复制标题
准确感知持续时间的神经基质：功能磁共振成像研究
DOI：
10.1016/j.neuropsychologia.2022.108145
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发表时间：
2022
期刊：
影响因子：
2.6
通讯作者：
Sadato N
中科院分区：
文献类型：
--
作者：
Hashiguchi M;Koike T;Morita T;Harada T;Denis Le Bihan;Sadato N
持续时间是物理世界的一个基本特征，它是主观感知和认知解释的。虽然这种感知与唤醒和内感受信号密切相关，但潜在的神经机制仍然难以捉摸。由于神经元对于整合来自外部世界的信息与生物体的内部状态至关重要，我们假设它可能在感知持续时间方面发挥核心作用，并有助于其估计准确性。我们进行了一项功能性磁共振成像研究，27名健康受试者执行时间和音高平分任务，使用相同的刺激。通过与两个在1 s（接近心率周期）的时间范围内具有短持续时间和长持续时间的参考物或低音调和高音调进行比较，参与者必须决定目标刺激是否在持续时间或音调上更接近参考刺激。通过对每个参与者的心理测量反应曲线分析，获得了短持续时间和长持续时间感知之间的时间平分点。二等分点和参考刺激持续时间的平均值之间的偏差被用作持续时间准确性的标记。与音高辨别相反，在背内侧前额叶皮层、双侧小脑和右前岛叶皮层（AIC）中发现了持续时间辨别特异性激活，并延伸到额下回（IFG）、顶下小叶和额极。右侧AIC和IFG的活性与时间辨别的准确性呈正相关。右AIC与持续时间的再生产有关，而右IFG则与分类决策有关。因此，在AIC中再现的所指持续时间与目标持续时间之间的比较可以发生在右IFG中。我们的结论是正确的AIC和IFG有助于时间持续的准确感知。
Time duration, an essential feature of the physical world, is perceived and cognitively interpreted subjectively. While this perception is deeply connected with arousal and interoceptive signals, the underlying neural mechanisms remain elusive. As the insula is critical for integrating information from the external world with the organism's inner state, we hypothesized that it might have a central role in the perception of time duration and contribute to its estimation accuracy. We conducted a functional magnetic resonance imaging study with 27 healthy participants performing temporal duration and pitch bisection tasks that used the same stimuli. By comparison with two referents with short and long duration in the time range of 1 s (close to the heart rate period), or low and high pitch, participants had to decide whether target stimuli were closer in duration or pitch to the referent stimuli. The temporal bisection point between short and long duration perception was obtained through a psychometric response curve analysis for each participant. The deviation between the bisection point and the average of reference stimuli durations was used as a marker of duration accuracy. Duration discrimination-specific activation, contrasted to pitch discrimination, was found in the dorsomedial prefrontal cortex, bilateral cerebellum, and right anterior insular cortex (AIC), extending to the inferior frontal gyrus (IFG), inferior parietal lobule, and frontal pole. The activity in the right AIC and IFG was positively correlated with the accuracy of duration discrimination. The right AIC is known to be related to the reproduction of duration, whereas the right IFG is involved in categorical decisions. Thus, the comparison between the referent durations reproduced in the AIC and the target duration may occur in the right IFG. We conclude that the right AIC and IFG contribute to the accurate perception of temporal duration.