Recent advances in understanding and managing liver transplantation.
Recent advances in understanding and managing liver transplantation.
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DOI：
10.12688/f1000research.8768.1
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Zanetto, Alberto
中科院分区：
文献类型：
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作者：
Russo, Francesco Paolo;Ferrarese, Alberto;Zanetto, Alberto
在过去的几十年里，肝移植（LT）已被确立为终末期肝病最有效的治疗方式。目前，LT后患者和移植物存活率非常好，1年和5年存活率分别为90%和80%。然而，肝移植的时机对于改善生存获益和结局至关重要。目前献血者的短缺和对LT的需求增加延长了等待时间。因此，根据地理区域，等候名单上的死亡率约为10- 15%。出于这个原因，在过去几年中，已经提出了已故供体LT的替代方案和优先考虑等待名单上的患者的新选择。
Liver transplantation (LT) has been established as the most effective treatment modality for end-stage liver disease over the last few decades. Currently, patient and graft survival after LT are excellent, with 1- and 5-year survival of 90% and 80%, respectively. However, the timing of referral to LT is crucial for improving survival benefit and outcome. The current shortage of donors and the increasing demand for LT currently lengthen the waiting time. Thus, waiting list mortality is about 10-15%, according to the geographical area. For this reason, over the last several years, alternatives to deceased donor LT and new options for prioritizing patients on the waiting list have been proposed.