The selenium status of women with a history of recurrent miscarriage
The selenium status of women with a history of recurrent miscarriage
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DOI：
10.1016/s0306-5456(01)00253-4
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发表时间：
2001-10-01
期刊：
影响因子：
--
通讯作者：
Lindow, SW
中科院分区：
文献类型：
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作者：
Al-Kunani, AS;Knight, R;Lindow, SW
目的探讨人血硒和头发硒水平与反复流产风险的关系。设计病例对照研究。研究对象两组非妊娠妇女：18例有一次或多次成功妊娠且无流产史的妇女对照组; 26名有反复流产史的女性（大于或等于3）随后没有成功怀孕（研究组）方法采用电感耦合等离子体质谱法（ICP-MS）测定静脉血和头发中硒的含量。各组妇女血硒水平无显著性差异。与对照组相比，复发性流产组的平均发硒水平显著降低（0.14 mug/g vs 0.34 mug/g）。对复发性流产组的进一步分析显示，血清或头发硒水平与产次无关。在对照组中，吃谷物和维生素补充剂的女性比例明显更高。结论与生育能力良好的对照组相比，反复流产妇女存在硒缺乏的证据。这种差异在头发样本中观察到，但在血清样本中没有观察到，因此可能不代表简单的营养缺乏。硒缺乏在流产中的重要性尚未确定。
Objective To assess the relationship between selenium levels in human blood and hair, and the risk of recurrent miscarriages.Design Case-control study.Participants Two groups of non-pregnant women: 18 women with one or more successful pregnancies and no history of miscarriage (control group); 26 women with a history of recurrent miscarriage (greater than or equal to 3) with no subsequent successful pregnancies (study group).Methods Samples of venous blood and scalp hair were collected and the selenium content analysed by inductively coupled plasma mass spectrometry.Results No significance difference was found between the level of selenium in the blood samples of the women in each group. There was a significant reduction in the mean hair selenium level in the recurrent miscarriage group compared with the control group (0.14 mug/g vs 0.34 mug/g). Further analysis of the recurrent miscarriage group revealed no relationship between levels of serum or hair selenium with parity. There was a significantly greater proportion of women in the control group who ate cereals, vitamin supplements. and liver or kidney.Conclusion There was evidence of selenium deficiency in women with recurrent miscarriages compared with a control group of women with a good reproductive performance. This difference was seen in hair samples but not serum samples and therefore may not represent a simple nutritional deficiency. The importance of selenium deficiency in miscarriage has still not been determined.