Oral sexual behaviors associated with prevalent oral human papillomavirus infection.
Oral sexual behaviors associated with prevalent oral human papillomavirus infection.
复制标题
DOI：
10.1086/597755
复制
发表时间：
2009-05-01
期刊：
影响因子：
--
通讯作者：
Gillison ML
中科院分区：
文献类型：
--
作者：
D'Souza G;Agrawal Y;Halpern J;Bodison S;Gillison ML
口腔人乳头瘤病毒(HPV)感染是口咽癌的原因之一。我们调查了在病例对照研究中增加口咽癌发生几率的性行为是否同样增加了对照组患者发生口腔HPV感染的几率。在门诊的332名对照患者中，有4.8%的人感染了HPV，在210名年龄在18-23岁的大学男性中，有2.9%的人感染了HPV。在对照组患者中，独立感染的几率随着一生口腔性伴侣(趋势P=.007)或阴道性伴侣(趋势P=.003)数量的增加而增加。在大学年龄的男性中，口腔HPV感染的几率随着最近口交伴侣(趋势为P=.046)或张嘴接吻伙伴(趋势为P=.023)的增加而增加，但阴道性伴侣的数量并不增加。口交和张嘴接吻与口腔HPV感染有关。
Oral human papillomavirus (HPV) infection is a cause of oropharyngeal cancer. We investigated whether sexual behaviors that elevated the odds of oropharyngeal cancer developing in a case-control study similarly elevated the odds of oral HPV infection developing among control patients. HPV infection was detected in 4.8% of 332 control patients from an outpatient clinic and in 2.9% of 210 college-aged men (age range, 18–23 years). Among control patients, the odds of infection developing independently increased with increases in the lifetime number of oral (P = .007, for trend) or vaginal sex partners (P = .003, for trend). Among college-aged men, the odds of oral HPV infection developing increased with increases in the number of recent oral sex partners (P = .046, for trend) or open-mouthed kissing partners (P = .023, for trend) but not vaginal sex partners. Oral sex and open-mouthed kissing are associated with the development of oral HPV infection.