Anterior cingulate cortex modulates the affective-motivative dimension of hyperosmolality-induced thirst
Anterior cingulate cortex modulates the affective-motivative dimension of hyperosmolality-induced thirst
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前扣带皮层调节高渗透压引起的口渴的情感动机维度
DOI：
10.1113/jp278301
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yi Ming
中科院分区：
文献类型：
--
作者：
Ma Longyu;Zhang Yuqi;Yue Lupeng;Zhang Xueying;Cui Shuang;Liu Feng Yu;Wan You;Yi Ming
神经影像学研究表明，前扣带皮层（ACC）始终被口渴激活，可能是口渴所要求的饮酒行为的情感动机的基础。但这一假设缺乏直接证据。本研究评估了注射不同浓度生理盐水的大鼠ACC神经元活动与饮酒行为之间的潜在相关性。我们观察到注射高渗盐水后ACC中c-Fos-阳性神经元数量增加，表明高渗口渴时ACC神经元强烈激活。增加发射率的推定ACC锥体神经元之前饮酒行为和正相关的总饮酒时间和总饮水量。ACC锥体神经元的化学发生抑制将饮酒行为从爆炸性和短暂的模式改变为渐进但更持久的模式，而不影响饮酒的总持续时间或总饮水量。总之，这些发现支持ACC在调节高渗引起的口渴的情感动机维度中的作用。
Neuroimaging studies have shown that the anterior cingulate cortex (ACC) is consistently activated by thirst and may underlie the affective motivation of drinking behaviour demanded by thirst. But direct evidence for this hypothesis is lacking. The present study evaluated potential correlations between ACC neuronal activity and drinking behaviour in rats injected with different concentrations of saline. We observed an increased number of c‐Fos‐positive neurons in the ACC after injection of hypertonic saline, indicating strong ACC neuronal activation under hyperosmotic thirst. Increased firing rates of putative ACC pyramidal neurons preceded drinking behaviour and positively correlated with both the total duration of drinking and the total amount of water consumed. Chemogenetic inhibition of ACC pyramidal neurons changed drinking behaviour from an explosive and short‐lasting pattern to a gradual but more persistent pattern, without affecting either the total duration of drinking or the total amount of water consumed. Together, these findings support a role of the ACC in modulating the affective‐motivative dimension of hyperosmolality‐induced thirst.