Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance -: The Insulin Resistance Atherosclerosis Study (IRAS)
Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance -: The Insulin Resistance Atherosclerosis Study (IRAS)
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DOI：
10.1161/01.atv.19.3.562
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发表时间：
1999-03-01
影响因子：
8.7
通讯作者：
Haffner, SM
中科院分区：
文献类型：
--
作者：
Festa, A;D'Agostino, R;Haffner, SM
高胰岛素血症与冠心病的发生有关。然而，对潜在的机制仍然知之甚少。高凝状态和纤维蛋白溶解受损可能是高胰岛素血症与动脉粥样硬化疾病的联系，并且已经表明胰岛素原而不是胰岛素是关键的病理生理因子。本研究的目的是在一个大的三种族人群中调查胰岛素及其前体与凝血和纤溶标志物的关系。纤溶酶原激活物抑制剂-1（派-1）抗原与胰岛素及其前体之间的强而独立的关系在不同的糖耐量状态下，PAI-1与空腹胰岛素[胰岛素原]的相关性是一致的（派-1与空腹胰岛素[胰岛素原]，在正常糖耐量组r=0.38 [r=0.34]，在糖耐量受损组r=0.42 [r=0.43];在2型糖尿病中r=0.38 [r=0.26]，所有P
Hyperinsulinemia is associated with the development of coronary heart disease. However, the underlying mechanisms are still poorly understood. Hypercoagulability and impaired fibrinolysis are possible candidates linking hyperinsulinism with atherosclerotic disease, and it has been suggested that proinsulin rather than insulin is the crucial pathophysiological agent. The aim of-this study was to investigate the relationship of insulin and its precursors to markers of coagulation and fibrinolysis in a large triethnic population. A strong and independent relationship between plasminogen activator inhibitor-1 (PAI-1) antigen and insulin and its precursors (proinsulin, 32-33 spit proinsulin) was found consistently across varying states of glucose tolerance (PAI-1 versus fasting insulin [proinsulin], r=0.38 [r=0.34] in normal glucose tolerance; r=0.42 [r=0.43] in impaired glucose tolerance; and r=0.38 [r=0.26] in type 2 diabetes; all P