Optical Detection of Ultrasound in Photoacoustic Imaging.
Optical Detection of Ultrasound in Photoacoustic Imaging.
复制标题
光声成像中超声检查的光学检测。
DOI：
10.1109/tbme.2016.2605451
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Zhang HF
中科院分区：
文献类型：
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作者：
Dong B;Sun C;Zhang HF
光声成像技术是一种基于光吸收对比度的生物样品研究的独特工具。在PA成像中，压电换能器通常用于检测激光诱导的超声波。然而，它们通常在高于100 MHz的超声频率下缺乏足够的宽带灵敏度，而它们庞大的尺寸和光学不透明的性质在将PA成像与常规光学成像模态集成时造成技术困难。为了克服这些局限性，光学方法的超声检测的发展，并显示其独特的应用在光声成像。我们提供了一个概述的光学方法的超声检测及其在PA成像中的应用的最新技术进展。描述灵敏度，带宽和角度响应的光学超声检测的一般理论框架也被引入。超声检测的光学方法可以在显著扩展的带宽上提供改进的检测角度和灵敏度。此外，其多功能变体还提供了其他优势，例如器件小型化、光学透明性、机械灵活性、最小的电气/机械串扰以及潜在的非接触PA成像。本文综述了光学超声检测方法及其未来的发展趋势，并展望了其在光声成像生物医学研究和临床诊断中的应用。
Photoacoustic (PA) imaging emerges as a unique tool to study biological samples based on optical absorption contrast. In PA imaging, piezoelectric transducers are commonly used to detect laser-induced ultrasonic waves. However, they typically lack adequate broadband sensitivity at ultrasonic frequency higher than 100 MHz while their bulky size and optically opaque nature cause technical difficulties in integrating PA imaging with conventional optical imaging modalities. To overcome these limitations, optical methods of ultrasound detection were developed and shown their unique applications in photoacoustic imaging. We provide an overview of recent technological advances in optical methods of ultrasound detection and their applications in PA imaging. A general theoretical framework describing sensitivity, bandwidth, and angular responses of optical ultrasound detection is also introduced. Optical methods of ultrasound detection can provide improved detection angle and sensitivity over significantly extended bandwidth. In addition, its versatile variants also offer additional advantages, such as device miniaturization, optical transparency, mechanical flexibility, minimal electrical/mechanical crosstalk, and potential noncontact PA imaging. The optical ultrasound detection methods discussed in this review and their future evolution may play an important role in photoacoustic imaging for biomedical study and clinical diagnosis.