Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer.
Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer.
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DOI：
10.1177/107327481602300405
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发表时间：
2016-10
期刊：
影响因子：
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通讯作者：
Munoz-Antonia T
中科院分区：
文献类型：
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作者：
Schabath MB;Cress D;Munoz-Antonia T
在过去的几十年里，肺癌一直是全球和美国最常见的癌症。除了肺癌发病率、死亡率和生存率在地理和性别上存在明显差异之外，也有越来越多的证据表明存在种族和民族差异。基于现有的已发表的数据，我们总结了与肺癌的种族和民族差异有关的当前知识和实质性发现。虽然本报告不是系统综述，但我们总结了目前与肺癌种族差异相关的知识和实质性发现，特别关注肺癌统计（发病率、死亡率和生存率）、吸烟、预防和早期发现以及肺癌基因组。最后，我们总结了一些可能导致种族和民族特定健康差异的系统级和提供者相关问题，并为未来可能减少不成比例的肺癌负担的策略提供了一些建议。尽管肺癌的发生是一个由外源性暴露（如吸烟）、遗传变异和躯体遗传事件积累驱动的多因素过程，但这一多因素过程似乎具有种族和民族差异，这反过来又影响了发病率、死亡率和生存率方面观察到的流行病学差异。
Globally and in the United States, lung cancer has been the most common cancer for the past several decades. In addition to the well-established geographical- and sex-specific differences in lung cancer incidence, mortality and survival, there is also growing evidence for racial and ethnic differences. Based on available published data, we present a summary of the current knowledge and substantive findings related to racial and ethnic differences in lung cancer. Although this report is not a systematic review, we summarized the current knowledge and substantive findings related to racial and ethnic differences in lung cancer with a particular focus on lung cancer statistics(incidence, mortality, and survival), cigarette smoking, prevention and early detection, and the lung cancer genome. Finally, we summarize some the systems-level and provider-related issues that likely contribute to racial and ethnic-specific health disparities and provide some suggestions for future strategies that may reduce the disproportionate burden of lung cancer. Although lung carcinogenesis is a multifactorial process driven by exogenous exposures (e.g., cigarette smoking), inherited genetic variations, and an accumulation of somatic genetic events, this multifactorial process appears to have racial and ethnic differences which in turn impacts the observed epidemiologic differences in incidence, mortality, and survival.