Optical imaging: Current applications and future directions
Optical imaging: Current applications and future directions
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DOI：
10.2967/jnumed.107.045799
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发表时间：
2008-01-01
影响因子：
9.3
通讯作者：
Luker, Kathryn E.
中科院分区：
文献类型：
--
作者：
Luker, Gary D.;Luker, Kathryn E.
光学技术，如生物发光和荧光，正在成为疾病和治疗中分子成像的强大新手段。结合创新的分子生物学和化学，研究人员开发了光学方法来成像体内的各种细胞和分子过程，包括蛋白质相互作用、蛋白质降解和蛋白酶活性。虽然光学成像主要用于小动物模型的研究，但光学分子成像将在几个领域转化为临床医学。在这篇综述中，我们总结了分子成像光学技术的最新进展及其对临床医学的潜在影响。
Optical techniques, such as bioluminescence and fluorescence, are emerging as powerful new modalities for molecular imaging in disease and therapy. Combining innovative molecular biology and chemistry, researchers have developed optical methods for imaging a variety of cellular and molecular processes in vivo, including protein interactions, protein degradation, and protease activity. Whereas optical imaging has been used primarily for research in small-animal models, there are several areas in which optical molecular imaging will translate to clinical medicine. In this review, we summarize recent advances in optical techniques for molecular imaging and the potential impact for clinical medicine.