The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration.
The freshwater planarian Schmidtea mediterranea: embryogenesis, stem cells and regeneration.
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发表时间：
2003
影响因子：
4
通讯作者：
A. Sánchez Alvarado
中科院分区：
文献类型：
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作者：
A. Sánchez Alvarado
200多年来，Planarians一直被用作研究发育和再生的模型。对这些动物的研究传统上集中在手术和药理学操作上。最近，对真涡虫的解剖在本质上变得更加分子化。数以千计的表达序列标签的分离和原位杂交，免疫细胞学和RNA介导的基因干扰的引入，打开了大门，基因发现和基因功能的研究在发育和再生过程中的涡虫。这些进展有望揭示再生和干细胞调节等基本生物学属性的机制。
Planarians have been used as a model to study development and regeneration for more than 200 years. Research on these animals has traditionally focused on surgical and pharmacological manipulations. Recently, the dissection of planarians has become more molecular in nature. The isolation of thousands of expressed sequence tags and the introduction of in situ hybridizations, immunocytology, and RNA-mediated gene interference has opened the door to gene discovery and to the study of gene function in planarians during development and regeneration. These advances promise to shed mechanistic insight into basic biological attributes such as regeneration and stem-cell regulation.