Understanding microRNAs regulation in heat shock response in the sea cucumber Apostichopus japonicas
Understanding microRNAs regulation in heat shock response in the sea cucumber Apostichopus japonicas
复制标题
了解刺参热激反应中 microRNA 的调控
DOI：
10.1016/j.fsi.2018.07.034
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发表时间：
2018-10-01
影响因子：
4.7
通讯作者：
Xu, Dongxue
中科院分区：
文献类型：
--
作者：
Li, Chao;Xu, Dongxue
The sea cucumber Apostichopus japonicas is a valuable species in China. The extreme high temperature in the summer often results in high mortality. MicroRNAs (miRNAs) play important post-transcriptional regulatory roles in gene expression and can influence heat shock response (HSR) greatly. In this study, we determined the expression profiles of miRNAs under heat stress (HS) in A. japonicas by using high-throughput sequencing technique. Among the differential expression miRNAs, we highlighted 41 differentially expressed miRNAs, many of which were involved in immunity process and disease regulation. Gene ontology and pathway analyses of putative target genes were also carried out. Cell-substrate adherens junction and cell-substrate junction were significantly enriched in GO analysis. Moreover, we made a correlation analysis between remarkable miRNAs and the differentially expressed genes (DEGs) in sea cucumbers under HS. We identified 17 key miRNA-target pairs potentially regulated HSR of sea cucumbers. These results will provide new insights about miRNAs regulation and molecular adaptive mechanisms in sea cucumbers under HS.
