Lymphocyte subpopulations in bronchopulmonary dysplasia.
Lymphocyte subpopulations in bronchopulmonary dysplasia.
复制标题
支气管肺发育不良中的淋巴细胞亚群。
DOI：
10.1055/s-2003-45387
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Cunningham-Rundles,Susanna
中科院分区：
文献类型：
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作者：
Ballabh,Praveen;Simm,Maciej;Kumari,Jaishree;Krauss,AlfredN;Jain,Ajey;Auld,PeterAM;Cunningham-Rundles,Susanna
炎症在支气管肺发育不良(BPD)的病因中起着关键作用。在目前的研究中，我们评估了39名患有呼吸窘迫综合征(RDS)的早产儿的淋巴细胞亚群，这些早产儿是否患有BPD。与出生后两周内没有发生BPD的婴儿相比，患有BPD的RDS婴儿的淋巴细胞绝对数较低(p<；0.020)，CD_4+T细胞的百分比和绝对数也较低。相比之下，非BPD组和BPD组CD3+CD8+淋巴细胞比例差异无统计学意义。BPD患儿B细胞百分率仅在出生后第7天显著下降，NK“明亮”细胞(CD56+)在所有RDS组均高度浓缩。有趣的是，BPD婴儿中表达CD62L的CD4+T细胞的百分比选择性地降低。作为一个整体，这些数据表明，CD4+T细胞的减少，特别是那些在组织迁移和免疫监测中起重要作用的细胞，可能是BPD发病的一个因素。
A key role for inflammation in the etiology of bronchopulmonary dysplasia (BPD) has been proposed. In the present study we have evaluated lymphocyte subpopulations in 39 premature infants with respiratory distress syndrome (RDS) who did or did not develop BPD. The absolute number of lymphocytes was lower among infants with RDS who developed BPD compared with those who did not over the first two weeks of life (p< 0.020) as were percentage and absolute number of CD4+ T cells. By contrast, the proportions of CD3+ CD8+ lymphocyte cells were not statistically different between non-BPD and BPD infants. B cell percentage was significantly decreased in BPD infants only on day 7. NK “bright” cells (CD56+) were highly enriched in all RDS groups. Interestingly, the percentage of CD4+ T cells expressing CD62L was selectively reduced in BPD infants. As a whole these data suggest that reduction of CD4+ T cells and especially those important in tissue migration and immune surveillance may be a factor in the pathogenesis of BPD.